Adherence to a Mediterranean diet and onset of disability in older persons
Adherence to a Mediterranean diet and onset of disability in older persons
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DOI：
10.1007/s10654-011-9611-4
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发表时间：
2011-09-01
影响因子：
13.6
通讯作者：
Barberger-Gateau, Pascale
中科院分区：
文献类型：
--
作者：
Feart, Catherine;Peres, Karine;Barberger-Gateau, Pascale
较高程度地坚持地中海式饮食可降低死亡率、心血管疾病和阿尔茨海默病的风险，但其与残疾的关系尚未得到评估。该研究的目的是调查地中海饮食（MeDi）的坚持与日常生活活动障碍之间的关系。研究样本由来自法国波尔多的 1,410 名个体组成，在 2001 年至 2002 年期间纳入三城市研究，并在 5 年内至少重新检查一次。根据食物频率调查问卷和 24 小时回忆计算对 MeDi 的依从性（评分为 0-9）。基础和工具性 ADL (B-IADL) 的残疾通过 Lawton-Brody 和 Katz 量表进行评估。统计分析按性别分层，并针对潜在的混杂因素进行调整。在多变量模型中，男性或女性中未强调 MeDi 依从性与 B-IADL 基线残疾之间的关联。随着时间的推移，B-IADL 出现残疾的风险与男性的 Medi 依从性没有显着相关。在女性中，MeDi 依从性与 B-IADL 中发生残疾的风险呈负相关（HR = 0.90，1 分的 95% 置信区间为 0.82-0.98）。随着时间的推移，Medi 依从性最高（得分 6-8）的女性比 Medi 类别最低（得分 0-3）的女性在 B-IADL 中发生残疾事件的相对风险降低了 50%（22-68%）。除了有据可查的对健康的有益影响外，坚持地中海式饮食还可能有助于减缓女性残疾的进程。
Higher adherence to a Mediterranean-type diet is linked to lower risk of mortality, cardiovascular disease and Alzheimer's disease while its association with disability has never been assessed. The aim of the study was to investigate the relation between adherence to a Mediterranean diet (MeDi) and disability in activities of daily living. The study sample consisted of 1,410 individuals from Bordeaux, France, included in 2001-2002 in the Three-City Study and re-examined at least once over 5 years. Adherence to a MeDi (scored as 0-9) was computed from a food frequency questionnaire and 24H recall. Disability in Basic and Instrumental ADL (B-IADL) was evaluated on the Lawton-Brody and Katz scales. Statistical analyses were stratified by gender and adjusted for potential confounders. No association between MeDi adherence and baseline disability in B-IADL was highlighted in men or in women in multivariate models. Risk of onset of disability in B-IADL over time was not significantly associated with MeDi adherence in men. In women, MeDi adherence was inversely associated with the risk of incident disability in B-IADL (HR = 0.90, 95% Confidence Interval 0.82-0.98 for 1 point of the score). Women with the highest MeDi adherence (score 6-8) had a 50% (22-68%) relative risk reduction of incident disability in B-IADL over time than women in the lowest MeDi category (score 0-3). In addition to its well-documented beneficial effects on health, adherence to a Mediterranean-type diet could contribute to slow down the disablement process in women.