Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma
Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma
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DOI：
10.1023/a:1026670723302
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发表时间：
1998-10-01
影响因子：
3.1
通讯作者：
Lin, XZ
中科院分区：
文献类型：
--
作者：
Chow, NH;Cheng, KS;Lin, XZ
应用免疫组织化学方法检测31例肝细胞癌组织和正常肝组织中成纤维细胞生长因子-1和成纤维细胞生长因子-2的表达。在正常肝脏的任何细胞成分中都不存在这两种血管生成因子的反应性。在31例肝细胞癌中，6例(19.4%)表达不同数量的成纤维细胞生长因子-1。除与组织学分级呈正相关(P=0.04)外，其表达模式与临床病理因素无明显相关性(P>；0.1)。没有肿瘤对其癌细胞中的成纤维细胞生长因子-2有反应。然而，这两种类型的肽都可以在肝细胞癌的细胞周围间质中被检测到。平均随访60个月，成纤维细胞生长因子-1的表达与患者的预后无关(P>；0.1)。我们的研究提示成纤维细胞生长因子-1在肝癌的发生中可能起到一定的作用。
This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver. For HCC, variable amounts of fibroblast growth factor-1 were detected in 6 of 31 cases (19.4%). There was no apparent relationship between the expression pattern and clinicopathologic factors (P > 0.1, respectively), except a positive correlation with histologic grading (P = 0.04). No tumor showed reactivity for fibroblast growth factor-2 in their cancer cells. However, both types of peptide could be demonstrated in the pericellular stroma of HCC. With a mean follow-up at 60 months, fibroblast growth factor-1 expression did not correlate with patients' outcome (P > 0.1). Our study suggested that fibroblast growth factor-1 appears to play a certain role in hepatocarcinogenesis.