Lower serum UA levels in Parkinson's disease patients in the Chinese population
Lower serum UA levels in Parkinson's disease patients in the Chinese population
复制标题
中国人群帕金森病患者血清UA水平较低
DOI：
10.1016/j.neulet.2012.02.077
复制
发表时间：
2012-04-18
影响因子：
2.5
通讯作者：
Tang，Bei-sha
中科院分区：
文献类型：
--
作者：
Zhang，Hai-nan;Guo，Ji-feng;Tang，Bei-sha
帕金森病(PD)是世界上第二常见的神经退行性疾病，氧化应激在其发病机制中起重要作用。尿酸(UA)是嘌呤代谢的产物，是一种天然的抗氧化剂，可以缓解帕金森病患者的氧化应激。最近的研究表明，血清尿酸水平与帕金森病的发病风险和帕金森病的运动症状进展有关，并提出尿酸可能是帕金森病潜在的病理生理机制的生物标志物。在我们的研究中，我们调查了中国人血清尿酸水平与帕金森病之间的关系。我们发现，在中国人群中，PD患者的血清UA水平低于正常对照组，且与PD的进展和病程有关。这些关联在两性中都观察到了，但高尿酸血症与男性比女性和老年人比年轻人更低的帕金森病发病率有更强的相关性。我们的结果表明，UA可能是PD的重要生物标志物，血清UA水平可能是PD诊断和疾病进展的有用生物标志物。
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and oxidative stress plays an important role in its pathogenesis. Uric acid (UA) is a product of purine metabolism and is a natural antioxidant that can relieve the oxidative stress that occurs in PD. Recent studies have indicated that the serum UA level are associated with a risk of PD and PD progression of motor symptoms and have proposed UA as a possible biomarker of the underlying pathophysiology of PD. In our study, we investigated the association between serum UA level and PD in a Chinese population. We found that the serum UA levels in PD patients were lower than the levels in control patients and were correlated with PD progression and duration in the Chinese population. These associations were observed in both genders, but hyperuricemia is more strongly associated with lower rates of PD among men compared to women and older people compared to younger people. Our results indicate that UA could be an important biomarker of PD and that the serum UA level could be a useful biomarker of PD diagnosis and disease progression.