Progresses in The Studies on Kindlin Family Members
Progresses in The Studies on Kindlin Family Members
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Kindlin家族成员研究进展
DOI：
10.3724/sp.j.1206.2010.00266
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
熊盈
中科院分区：
文献类型：
--
作者：
龚小卫;姜勇;熊盈
Kindlins是一组新发现的粘着斑蛋白，包括Kindlin-1、Kindlin-2和Kindlin-3。Kindlins具有高度的同源性和进化保守性，参与了许多重要的细胞生理功能的调节，如细胞迁移、增殖和分化。通过与β整合素的细胞质结构域相互作用，Kindlins在细胞-细胞外基质黏附、细胞-细胞连接、细胞骨架重塑和整合素介导的双向信号转导中发挥重要作用。Kindlins的异常与一些遗传性疾病、心血管疾病、疾病的发生和发展有关进一步阐明Kindlins和整合素相互作用调节细胞功能的机制，不仅可以提高我们对细胞黏附和迁移的认识，也将有助于Kindlins相关疾病的治疗。
Kindlins are a group of newly identified focal adhesion proteins,including Kindlin-1,Kindlin-2,and Kindlin-3.Kindlins possess high homogeneity and conservation evolutionarily,involving in the regulation of many important cellular physiological functions,such as cell migration,proliferation,and differentiation.Through the interaction with the cytoplasmic domain of β integrin,Kindlins play important roles in cell-extracellular matrix adhesion,cell-cell junctions,cytoskeleton remodeling,and integrin-mediated bidirectional signaling.Abnormities of Kindlins are associated with the etiology and progression of some genetic diseases,cardiovascular diseases,and cancers.The further elucidation of the mechanisms regulating the cellular functions mediated by the interaction between Kindlins and integrins will not only improve our knowledge about cell adhesion and migration,but also the therapeutics of Kindlins-related diseases.