Discriminative stimulus properties of naloxone.
Discriminative stimulus properties of naloxone.
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纳洛酮的辨别刺激特性。
DOI：
10.1007/bf00432760
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发表时间：
1982
影响因子：
3.4
通讯作者：
Leander,JD
中科院分区：
文献类型：
--
作者：
Carter,RB;Leander,JD
非阿片类药物依赖的鸽子进行了培训，以区分IM注射30.0毫克/公斤纳洛酮水在一个程序中，其中15个连续的反应，两个关键之一，导致粮食介绍。纳洛酮适当的反应是最大的纳洛酮剂量等于和大于训练剂量。纳洛酮辨别性提示的开始是快速的（小于5分钟），提示的持续时间是短的（小于60分钟）。纳洛酮（1.0-10.0 mg/kg）、喷他佐辛（1.0-10.0 mg/kg）、左洛啡烷（1.0-30.0 mg/kg）和纳洛啡（3.0-30.0 mg/kg）产生剂量依赖性的纳洛酮适当反应增加，100%消除纳洛酮关键选择。相比之下，环唑辛、普罗夫多和二丙诺啡在剂量达到动物无反应的剂量时，仅产生中等程度的纳洛酮适当反应。吗啡总是产生水的关键选择。这些结果表明，纯阿片类拮抗剂，如纳洛酮，在非阿片类药物依赖性动物中具有区别性刺激作用，这些刺激作用是由某些其他阿片类拮抗剂共享的，并且这些作用与纯阿片类激动剂，如吗啡产生的作用是不同的。
Nonopioid-dependent pigeons were trained to discriminate IM injections of 30.0 mg/kg naloxone from water in a procedure in which 15 consecutive responses on one of two keys resulted in grain presentation. Naloxone-appropriate responding was maximal at doses of naloxone equal to and greater than the training dose. The onset of the naloxone discriminative cue was rapid (less than 5 min) and the duration of the cue was short (less than 60 min). Naltrexone (1.0–10.0 mg/kg), pentazocine (1.0–10.0 mg/kg), levallorphan (1.0–30.0 mg/kg), and nalorphine (3.0–30.0 mg/kg) produced dose-dependent increases in naloxone-appropriate responding, occasioning 100% naloxone-key selections. In contrast, cyclazocine, profadol, and diprenorphine, at doses up to those at which animals did not respond, produced only intermediate degrees of naloxone-appropriate responding. Morphine always produced selection of the water key. These results demonstrate that a pure opioid antagonist, such as naloxone, has discriminative stimulus effects in the nonopioid-dependent animal, that these stimulus effects are shared by certain other opioid antagonists, and that these effects are distinguishable from those produced by pure opioid agonists, such as morphine.