Eosinophils increase airway sensory nerve density in mice and in human asthma.
Eosinophils increase airway sensory nerve density in mice and in human asthma.
复制标题
DOI：
10.1126/scitranslmed.aar8477
复制
发表时间：
2018-09-05
影响因子：
17.1
通讯作者：
Jacoby DB
中科院分区：
文献类型：
--
作者：
Drake MG;Scott GD;Blum ED;Lebold KM;Nie Z;Lee JJ;Fryer AD;Costello RW;Jacoby DB
在哮喘中，气道神经功能障碍会导致支气管过度收缩和咳嗽。众所周知，嗜酸性粒细胞会改变神经功能，并且 50% 至 60% 的哮喘患者存在气道嗜酸性粒细胞增多。然而，嗜酸性粒细胞对气道神经结构的影响尚未确定。我们测试了嗜酸性粒细胞是否改变气道神经结构，并测量了这些变化的生理后果。我们对患有和不患有嗜酸性粒细胞性哮喘的人进行的研究结果表明，与轻度间歇性哮喘患者和健康受试者相比，中度持续性哮喘患者的气道神经支配和 P 物质表达增加。神经支配的增加与支气管扩张剂反应性的缺乏和刺激敏感性的增加有关。在嗜酸性粒细胞气道炎症的小鼠模型中，神经密度的增加和气道高反应性是由嗜酸性粒细胞介导的。我们的结果表明，气道神经重塑是嗜酸性粒细胞性哮喘中刺激敏感性增加和气道反应过度的关键机制。
In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is well established that eosinophils alter nerve function and that airway eosinophilia is present in 50 to 60% of asthmatics. However, the effects of eosinophils on airway nerve structure have not been established. We tested whether eosinophils alter airway nerve structure and measured the physiological consequences of those changes. Our results in humans with and without eosinophilic asthma showed that airway innervation and substance P expression were increased in moderate persistent asthmatics compared to mild intermittent asthmatics and healthy subjects. Increased innervation was associated with a lack of bronchodilator responsiveness and increased irritant sensitivity. In a mouse model of eosinophilic airway inflammation, the increase in nerve density and airway hyperresponsiveness were mediated by eosinophils. Our results implicate airway nerve remodeling as a key mechanism for increased irritant sensitivity and exaggerated airway responsiveness in eosinophilic asthma.
登录
查看更多内容
DOI：
10.1165/rcmb.2005-0196oc
发表时间：
2006-06-01
影响因子：
6.4
作者：
Durcan, Niamh;Costello, Richard W.;Walsh, Marie-Therese
通讯作者：
Walsh, Marie-Therese
影响因子：
15.9
作者：
Fryer, AD;Costello, RW;Bochner, BS
通讯作者：
Bochner, BS
DOI：
10.1152/ajplung.00271.2007
发表时间：
2008-03-01
影响因子：
4.9
作者：
Gu, Qihai;Wiggers, Michelle E.;Lee, Lu-Yuan
通讯作者：
Lee, Lu-Yuan
DOI：
10.1016/j.clim.2016.08.009
发表时间：
2016-10
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Hennigan K;Conroy PJ;Walsh MT;Amin M;O'Kennedy R;Ramasamy P;Gleich GJ;Siddiqui Z;Glynn S;McCabe O;Mooney C;Harvey BJ;Costello RW;McBryan J
通讯作者：
McBryan J
影响因子：
14.2
作者：
Chu, HW;Kraft, M;Martin, RJ
通讯作者：
Martin, RJ