Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects.
Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects.
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DOI：
10.1016/j.biomaterials.2010.02.052
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发表时间：
2010-06
期刊：
影响因子：
14
通讯作者：
Berkland, Cory
中科院分区：
文献类型：
--
作者：
Wang, Qun;Wang, Jinxi;Lu, Qinghua;Detamore, Michael Scott;Berkland, Cory
骨填充剂已成为修复骨骼缺陷通常所需的侵入性手术的替代方案。为了加速愈合，需要实现这些材料的控制释放。在这里，带相反电荷的聚（d,l-乳酸-乙醇酸）（PLGA）纳米颗粒被用来制造粘性胶体凝胶，作为可注射的载药填充剂，以促进骨缺损的愈合。胶体通过静电力自组装，形成稳定的 3D 网络，可以将其挤压或模制成所需的形状。由于随着施加的剪切力的增加，颗粒间相互作用被破坏，胶体凝胶表现出剪切稀化行为。一旦外力去除，胶体凝胶的内聚性能就恢复了。在负载地塞米松的胶体凝胶中也观察到类似的可逆性和剪切稀化行为。当药物被封装在 PLGA 纳米颗粒中并且简单地将药物与胶体凝胶混合时，在两个月内观察到接近零级的地塞米松释放，在一个月内显示出相似的动力学。假塑性材料特性促进了手术放置，体内观察表明 PLGA 胶体凝胶刺激大鼠颅骨缺损中的骨传导性骨形成。
Bone fillers have emerged as an alternative to the invasive surgery often required to repair skeletal defects. Achieving controlled release from these materials is desired for accelerating healing. Here, oppositely-charged Poly (d,l-lactic-co-glycolic acid) (PLGA) nanoparticles were used to create a cohesive colloidal gel as an injectable drug-loaded filler to promote healing in bone defects. The colloid self-assembled through electrostatic forces resulting in a stable 3-D network that may be extruded or molded to the desired shape. The colloidal gel demonstrated shear-thinning behavior due to the disruption of interparticle interactions as the applied shear force was increased. Once the external force was removed, the cohesive property of the colloidal gel was recovered. Similar reversibility and shear-thinning behavior were also observed in colloidal gels loaded with dexamethasone. Near zero-order dexamethasone release was observed over two months when the drug was encapsulated in PLGA nanoparticles and simply blending the drug with the colloidal gel showed similar kinetics for one month. Surgical placement was facilitated by the pseudoplastic material properties and in vivo observations demonstrated that the PLGA colloidal gels stimulated osteoconductive bone formation in rat cranial bone defects.
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影响因子：
56.9
作者：
Klajn, Rafal;Bishop, Kyle J. M.;Grzybowski, Bartosz A.
通讯作者：
Grzybowski, Bartosz A.
影响因子：
8.6
作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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