Ischemia-reperfusion Injury in Sickle Cell Anemia Relationship to Acute Chest Syndrome, Endothelial Dysfunction, Arterial Vasculopathy, and Inflammatory Pain
Ischemia-reperfusion Injury in Sickle Cell Anemia Relationship to Acute Chest Syndrome, Endothelial Dysfunction, Arterial Vasculopathy, and Inflammatory Pain
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DOI：
10.1016/j.hoc.2013.11.005
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发表时间：
2014-04-01
影响因子：
2.4
通讯作者：
Hebbel, Robert P.
中科院分区：
文献类型：
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作者：
Hebbel, Robert P.
缺血-再灌注（I/R）生理学，也称为再灌注损伤，在人类疾病状态中引起血管和组织损伤。这篇综述介绍了为什么镰状细胞性贫血应该以这种方式概念化，以及I/R生理学如何解释镰状细胞性贫血的血管病理生物学和临床疾病的特征方面的起源。I/R的性质及其与镰状细胞性贫血的相关性进行了讨论，重点是急性胸部综合征，血管内皮功能障碍与血管调节异常，循环的威利斯血管病变，炎症性疼痛。从这个角度来看镰状病阐明了定义病理生理学，并确定了一个新的潜在的治疗靶点主机。
Ischemia-reperfusion (I/R) physiology, also called reperfusion injury, instigates vascular and tissue injury in human disease states. This review describes why sickle cell anemia should be conceptualized in this fashion and how I/R physiology explains the genesis of characteristic aspects of vascular pathobiology and clinical disease in sickle cell anemia. The nature of I/R and its relevance to sickle cell anemia are discussed, with an emphasis on the acute chest syndrome, endothelial dysfunction with aberrant vasoregulation, circle of Willis vasculopathy, and inflammatory pain. Viewing sickle disease from this perspective elucidates defining pathophysiology and identifies a host of novel potential therapeutic targets.