Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community
Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community
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DOI：
10.2176/nmc.48.197
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发表时间：
2008-05-01
影响因子：
1.9
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Hiraoka, Kotaro;Meguro, Kenichi;Mori, Etsuro
通过对随机抽取的170名65岁以上老年居民的社区研究数据的回顾分析，调查了社区特发性正常压力性脑积水(NPH)的患病率。复习受试者的磁共振(MR)影像，以了解特发性NPH的特殊结构特征，即高凸度和高中线区域的脑室增大和脑脊液(CSF)间隙狭窄。根据神经学检查、健康问卷、简易智力状态检查和临床痴呆量表的记录，评估特发性NPH、步态障碍、尿失禁和认知功能障碍的临床特征。170名受试者中有13人的侧脑室扩大大于埃文斯指数的0.3。5名受试者(2.9%)在高凸度/中线同时表现为脑室扩大和脑脊液间隙狭窄。所有五名有这些磁共振成像体征的受试者都有认知障碍，一人有步态障碍，一人有尿失禁。目前的研究发现，2.9%的社区老年受试者表现出与特发性NPH一致的放射学和临床特征。
The prevalence of idiopathic normal-pressure hydrocephalus (NPH) in a community was investigated by retrospective analysis of data from a previous community-based study of 170 randomly selected elderly residents aged 65 years or older. Magnetic resonance (MR) images of the subjects were reviewed for the specific structural features of idiopathic NPH, i.e. ventricular enlargement and narrow cerebrospinal fluid (CSF) space at high convexity and high midline areas. The clinical features of idiopathic NPH, gait disturbance, urinary incontinence, and cognitive impairment, were evaluated on the basis of records of the subjects' neurological examinations, a health questionnaire, the Mini-Mental State Examination, and Clinical Dementia Rating. Thirteen of the 170 subjects showed lateral ventricular enlargement greater than 0.3 on Evans' index. Five subjects (2.9%) demonstrated both ventricular enlargement and narrow CSF space at the high convexity/midline. All five subjects with these MR imaging signs had cognitive impairment, one had gait disturbance, and one had urinary incontinence. The present study found 2.9% of community-dwelling elderly subjects showed radiological and clinical features consistent with idiopathic NPH.