DOSE-DEPENDENT PAIN AND MECHANICAL HYPERALGESIA IN HUMANS AFTER INTRADERMAL INJECTION OF CAPSAICIN
DOSE-DEPENDENT PAIN AND MECHANICAL HYPERALGESIA IN HUMANS AFTER INTRADERMAL INJECTION OF CAPSAICIN
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DOI：
10.1016/0304-3959(89)90079-1
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发表时间：
1989-07-01
期刊：
影响因子：
7.4
通讯作者：
LAMOTTE, RH
中科院分区：
文献类型：
--
作者：
SIMONE, DA;BAUMANN, TK;LAMOTTE, RH
将不同剂量的辣椒素皮内注射到受试者的前臂后，获得了疼痛和机械性痛敏的心理物理学测量结果。每个受试者都接受了10微升的注射，并注射了0.01、0.1、1、10和100微克的辣椒素。用量值估计法确定辣椒素剂量与疼痛程度和持续时间的关系。除了疼痛，辣椒素还会产生红晕和机械性痛觉过敏。测量红斑面积、机械性痛敏的面积和时程，作为辣椒素剂量的函数。根据所有受试者的平均反应，疼痛的程度和持续时间以剂量的负加速函数增加。与安慰剂相比，辣椒素产生更多疼痛的最低剂量是0.1ug。机械性痛觉过敏的面积和持续时间也随着剂量的增加而增加。产生机械性痛觉过敏区域的辣椒素的最低剂量为0.1ug。注射后几秒钟内就出现了痛觉过敏区域。在10和100微克剂量下，痛觉过敏面积在注射后5分钟和7分钟内达到最大值，然后逐渐减小，分别在15分钟和137分钟内消失。辣椒素的剂量分别为1、10和100微克，依次产生更大的耀斑区域。结果表明，人类可以以剂量依赖的方式衡量辣椒素产生的疼痛程度。此外，疼痛的持续时间、机械性痛觉过敏的面积和持续时间以及红斑的面积都是剂量依赖性的。结论：皮内注射辣椒素将为疼痛和痛敏的心理物理和神经生理学平行研究提供一种有用的方法。
Psychophysical measurements of pain and mechanical hyperalgesia were obtained following different doses of capsaicin injected intradermally into the forearms of human subjects. Each subject received a 10 .mu.l injection of the vehicle and capsaicin doses of 0.01, 0.1, 1, 10 and 100 .mu.g. The relationship between capsaicin dose and the magnitude and duration of pain was determined using the method of magnitude estimation. In addition to pain, capsaicin produced a flare and mechanical hyperalgesia. The area of flare and the area and time course of mechanical hyperalgesia were measured as a function of the dose of capsaicin. The magnitude and duration of pain, based on averaged responses of all subjects, increased as a negatively accelerating function of dose. The lowest dose of capsaicin to produce more pain than the vehicle was 0.1 .mu.g. The area and duration of mechanical hyperalgesia also increased as a negatively accelerating function of dose. The lowest dose of capsaicin to produce an area of mechanical hyperalgesia was 0.1 .mu.g. An area of hyperalgesia was present within seconds following injection. For doses of 10 and 100 .mu.g, the area of hyperalgesia grew to reach a maximum within 5 and 7 min following the injection and gradually decreased, disappearing within 15 and 137 min, respectively. Capsaicin doses of 1, 10 and 100 .mu.g produced successively greater areas of flare. The results demonstrate that humans can scale the magnitude of pain produced by capsaicin in a dose-dependent fashion. Further, the duration of pain, the area and duration of mechanical hyperalgesia, and the area of flare are dose-dependent. It is concluded that intradermal injection of capsaicin will provide a useful method of carrying out parallel psychophysical and neurophysiological studies of pain and hyperalgesia.