PROLIFERATIVE RESPONSE OF THE SPLEEN AND LIVER TO HEMOLYSIS
PROLIFERATIVE RESPONSE OF THE SPLEEN AND LIVER TO HEMOLYSIS
复制标题
脾脏和肝脏对溶血的增殖反应
DOI：
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发表时间：
1965
影响因子：
15.3
通讯作者：
R. Macdonald
中科院分区：
文献类型：
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作者：
J. H. Jandl;N. Files;S. B. Barnett;R. Macdonald
在注射氚化胸苷的大鼠中进行的联合化学和放射自显影研究表明，急性红细胞隔离刺激网状内皮（RE）增殖。在脾脏中，DNA合成在边缘区中受到最显著的刺激，边缘区也是红细胞隔离的起始部位。这种增殖反应涉及几个分裂步骤，并最终导致红髓定植，脾天然的所有细胞系数量增加。在脾和肝中，巨噬细胞和沿岸的细胞中也发生广泛的分裂刺激，其仅涉及1或2个分裂步骤。慢性代偿性溶血性贫血实现大鼠注射苯肼引起功能过度活跃的RE系统，包括增加螯合功能和高丙种球蛋白血症。停止注射后，脾脏增生未完全消退。在人类中，慢性非免疫性溶血性贫血的脾肿大，即遗传性球形红细胞增多症，被发现涉及所有脾细胞成分的显著（平均：8倍）增生。急性或慢性增殖反应似乎都不是由免疫或“毒性”刺激引起的，研究结果支持RE系统的大小是其颗粒“工作负荷”的函数的观点。“这表明免疫反应的细胞增殖方面可能取决于非特异性的，通常是颗粒刺激。在长时间刺激后，RES的增生可能变得部分不可逆。
Combined chemical and autoradiographic studies in rats injected with tritiated thymidine indicate that acute red cell sequestration stimulates reticuloendothelial (RE) proliferation. In the spleen DNA synthesis is most markedly stimulated in the marginal zone which is also the initial site of red cell sequestration. This proliferative response involves several division steps and eventuates in a colonization of the red pulp with increased numbers of all cell lines native to the spleen. In both spleen and liver there occurs also a generalized stimulation of division in the macrophages and littoral cells which involves only 1 or 2 division steps. Chronic compensated hemolytic anemia achieved in rats by injections of phenylhydrazine caused functional overactivity of the RE system, including increased sequestering function and hypergammaglobulinemia. This splenic hyperplasia did not entirely regress after cessation of the injections. In man the splenomegaly of a chronic non-immunological hemolytic anemia, hereditary spherocytosis, was found to involve a marked (average: 8-fold) hyperplasia of all spleen cellular elements. Neither the acute nor chronic proliferative reaction appears to arise from immunological or "toxic" stimuli and the findings support the view that the size of the RE system is a function of its particulate "work load." It is suggested that the cytoproliferative aspects of immune responses may depend upon non-specific, usually particulate stimulation. After prolonged stimulation, hyperplasia of the RES may become partly irreversible.