Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance
Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance
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DOI：
10.1523/jneurosci.2550-20.2021
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发表时间：
2021-04-21
影响因子：
5.3
通讯作者：
Braver, Todd S.
中科院分区：
文献类型：
--
作者：
Yee, Debbie M.;Crawford, Jennifer L.;Braver, Todd S.
人类可以将来自不同动机激励的价值信号无缝地联合收割机组合起来，但人们还不清楚这些信号是如何“捆绑”在大脑中以调节认知控制的。背侧ACC（dACC）的理论整合的动机价值维度的服务目标导向的行动，虽然这一假设还没有得到严格的证实。在本研究中，我们研究了人类dACC在动机激励整合中的作用。健康的年轻成年男性和女性在进行量化液体（例如，果汁，中性，盐水）和金钱激励对认知任务绩效的影响。货币激励调制的审判由审判dACC激活，而块相关的影响，液体激励对dACC活性进行了观察。当捆绑在一起时，与激励相关的dACC调制预测了认知表现和自我报告动机评级的波动。统计中介分析表明，dACC根据其综合主观激励价值对激励进行编码，并且该价值信号与任务绩效最密切相关。最后，我们证实，这些激励整合效应有选择地存在于dACC。总之，结果支持一个帐户，其中dACC整合动机信号计算目标导向的认知控制的预期值。
Humans can seamlessly combine value signals from diverse motivational incentives, yet it is not well understood how these signals are "bundled" in the brain to modulate cognitive control. The dorsal ACC (dACC) is theorized to integrate motivational value dimensions in the service of goal-directed action, although this hypothesis has yet to receive rigorous confirmation. In the present study, we examined the role of human dACC in motivational incentive integration. Healthy young adult men and women were scanned with fMRI while engaged in an experimental paradigm that quantifies the combined effects of liquid (e.g., juice, neutral, saltwater) and monetary incentives on cognitive task performance. Monetary incentives modulated trial-by-trial dACC activation, whereas block-related effects of liquid incentives on dACC activity were observed. When bundled together, incentive-related dACC modulation predicted fluctuations in both cognitive performance and self-report motivation ratings. Statistical mediation analyses suggest that dACC encoded the incentives in terms of their integrated subjective motivational value, and that this value signal was most proximally associated with task performance. Finally, we confirmed that these incentive integration effects were selectively present in dACC. Together, the results support an account in which dACC integrates motivational signals to compute the expected value of goal-directed cognitive control.