Prevalence of metabolic syndrome (MS) in children and adolescents with varying degrees of obesity
Prevalence of metabolic syndrome (MS) in children and adolescents with varying degrees of obesity
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DOI：
10.1111/j.1365-2265.2007.03115.x
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Larizza, D.
中科院分区：
文献类型：
--
作者：
Calcaterra, V.;Klersy, C.;Larizza, D.
目的儿童肥胖症是一种常见的健康问题，尤其是在代谢综合征（MS）中起着重要作用。我们估计MS的患病率在高加索儿童和青少年不同程度的obesity.Patients和方法，我们研究了191肥胖[体重指数（BMI）> 97百分位]的儿童和青少年。基于阈值BMI z分数对肥胖进行分层，并且将受试者分类为中度（z分数2-2.5）或重度肥胖（z分数> 2.5）。76名非肥胖受试者被招募到对照组。其中31人体重正常（BMI <第75百分位）和45超重如果患者符合以下年龄和性别标准中的三个或更多个，则将其分类为患有MS：BMI >第97百分位，甘油三酯水平>第95百分位，高密度脂蛋白（HDL）胆固醇水平<第5百分位，收缩压或舒张压>第95百分位数和葡萄糖耐量受损（2小时血糖水平：7.8-11.1 mmol/l）。结果MS的总患病率为13.9%，其中中度肥胖组为12.0%，重度肥胖组为31.1%，青春期前组为HOMA-IR ≥ 2.5，青春期组为HOMA-IR > 4;无超重或正常体重者符合MS标准，MS发生率随BMI类别的增加而增加（P < 0.001）。严重肥胖患者的风险增加了三倍，相对于中度肥胖patients.Conclusions的MS的患病率是较高的肥胖，而不是非肥胖的受试者和肥胖的严重程度增加。
Objective Childhood obesity is increasingly common and is associated with health problems; in particular, obesity plays a central role in the metabolic syndrome (MS). We estimated the prevalence of MS in Caucasian children and adolescents with varying degrees of obesity.Patients and methods We studied 191 obese [body mass index (BMI) > 97th percentile] children and adolescents. Obesity was stratified on the basis of a threshold BMI z-score and subjects were classified as moderately (z-score 2-2.5) or severely obese (z-score > 2.5). Seventy-six, nonobese subjects were recruited into a comparison group. Thirty-one of them were of normal weight (BMI < 75th percentile) and 45 overweight (BMI 75th-97th percentile).Patients were classified as having MS if they met three or more of the following criteria for age and sex: BMI > 97th percentile, triglyceride levels > 95th percentile, high density lipoprotein (HDL) cholesterol level < 5th percentile, systolic or diastolic blood pressure > 95th percentile and impaired glucose tolerance (blood glucose level: 7.8-11.1 mmol/l at 2 h). Insulin resistance was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) and impaired insulin sensitivity was defined as a HOMA-IR >= 2.5 in prepubertal patients and HOMA-IR > 4 in pubertal subjects.Results The overall prevalence of MS was 13.9% and was present in 12.0% of moderately obese and 31.1% of severely obese subjects; no overweight or normal weight subjects met the criteria for MS. The rate of the MS increased progressively with increasing BMI categories (P < 0.001). Severely obese patients had a threefold increased risk with respect to moderately obese patients.Conclusions The prevalence of the MS is higher in obese as opposed to nonobese subjects and increases with severity of obesity.