Retinal circulatory abnormalities in type 1 diabetes.
Retinal circulatory abnormalities in type 1 diabetes.
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发表时间：
1994-06
影响因子：
4.4
通讯作者：
G. Feke;S. Buzney;H. Ogasawara;N. Fujio;D. Goger;N. Spack;K. Gabbay
中科院分区：
文献类型：
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作者：
G. Feke;S. Buzney;H. Ogasawara;N. Fujio;D. Goger;N. Spack;K. Gabbay
目的 量化 1 型糖尿病患者的视网膜循环异常； 1 糖尿病；比较患者和非糖尿病对照者测量的主要颞视网膜动脉的血流速度和血流量以及总视网膜动脉横截面；确定哪些因素与患者组内测量到的异常相关。方法采用激光多普勒技术和单色眼底照相技术测量39例病程7～20年的1型糖尿病患者和13例年龄匹配的非糖尿病对照者的视网膜循环参数。测量了所有受试者的血压、眼压和心率。测量了患者的糖化血红蛋白。使用标准化彩色眼底照相和荧光素血管造影评估视网膜病变。结果 患者的视网膜总动脉横截面平均比对照组高 17% (P = 0.007)，并且随着糖尿病病程的延长而增加 (P = 0.006)。患者的动脉血流速度平均比对照组低 33% (P = 0.0001)，并且随着糖尿病病程的延长而降低 (P = 0.03)。结论 无视网膜病变或背景视网膜病变的 1 型糖尿病患者的视网膜循环特点是主动脉扩张且血流速度降低。较大视网膜动脉的扩张，伴随着这些血管中血流阻力的降低，似乎抵消了较小视网膜血管水平上血流阻力的增加。
PURPOSE To quantify retinal circulatory abnormalities in patients with type 1 diabetes; to 1 diabetes; to compare blood speed and blood flow in major temporal retinal arteries as well as total retinal arterial cross-section measured in patients to that measured in controls without diabetes; to determine which factors are related to the measured abnormalities within the patient group. METHODS The laser Doppler technique and monochromatic fundus photography were used to measure retinal circulatory parameters in 39 patients with type 1 diabetes with duration of diabetes between 7 and 20 years and 13 age-matched controls without diabetes. Blood pressure, intraocular pressure, and heart rate were measured in all subjects. Glycosylated hemoglobin was measured in the patients. Retinopathy was assessed using standardized color fundus photography and fluorescein angiography. RESULTS Total retinal arterial cross-section was, on average, 17% higher (P = 0.007) in the patients than in the controls, and it increased with increasing duration of diabetes (P = 0.006). Arterial blood speed was, on average, 33% lower (P = 0.0001) in the patients than in the controls, and it decreased with increasing duration of diabetes (P = 0.03). CONCLUSIONS The retinal circulation of patients with type 1 diabetes with no retinopathy or background retinopathy is characterized by dilated major arteries with reduced blood speeds. Dilation of the larger retinal arteries, with the accompanying decrease in vascular resistance to flow in those vessels, appears to counteract an increase in resistance to flow at the level of the smaller retinal vessels.