Benzophenone photoprobes for phosphoinositides, peptides and drugs
Benzophenone photoprobes for phosphoinositides, peptides and drugs
复制标题
DOI：
10.1111/j.1751-1097.1997.tb08548.x
复制
发表时间：
1997-02-01
影响因子：
3.3
通讯作者：
Chaudhary, A
中科院分区：
文献类型：
--
作者：
Prestwich, GD;Dorman, G;Chaudhary, A
二苯甲酮(BP)和相关的芳基酮光生团已成为高效共价修饰结合蛋白疏水区域的可光激活基团，这些结合蛋白包括识别肽激素的酶和受体、(寡)核苷酸和核苷、磷脂酰肌醇多聚磷酸盐和各种治疗分子。本文介绍了BP作为光亲和标记的优点，并列举了近3年来含BP的配体在生物化学中应用的具体例子。
Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high-efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligo)nucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used in biochemistry.