Stimulation of the locus coeruleus suppresses trigeminal sensorimotor function in the rat
Stimulation of the locus coeruleus suppresses trigeminal sensorimotor function in the rat
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DOI：
10.1016/s0361-9230(00)00426-3
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发表时间：
2000-12-01
影响因子：
3.8
通讯作者：
Kawawa, T
中科院分区：
文献类型：
--
作者：
Matsutani, K;Tsuruoka, M;Kawawa, T
蓝斑核（LC）参与了脊髓感觉运动功能的调节。本研究旨在探讨电刺激LC对三叉神经系统感觉运动功能的影响，研究了以下两种由三叉脑干感觉清晰复合体介导的感觉运动行为：(1)颞下颌关节（TMJ）受压引起的咬肌活动；(2)牙髓电刺激引起的二腹肌活动，导致下颌张开反射。在第一种情况下，与对照组相比，10、30和50 μ a的LC刺激分别导致咬肌肌电图（EMG）活动幅度降低70%、68%和55%（没有LC刺激）。在10、30和50 μ a的LC刺激下，咬肌肌电活动的阈值强度分别增加到对照组的106%、111%和121%。在第二种情况下，30 μ a的LC刺激时，二腹肌肌电反应的阈值强度下降到对照组的42%。这些结果表明，LC的下行影响可以抑制三叉神经的感觉运动功能。(C) 2001爱思唯尔科学公司
The nucleus locus coeruleus (LC) has been implicated in the modulation of the spinal sensorimotor function. The aim of the present study was to examine the effect of electrical stimulation of the LC on sensorimotor function in the trigeminal system, The following two cases of sensorimotor behaviors mediated by the trigeminal brainstem sensory nu clear complex were examined: (1) the activity of the masseter muscle evoked by pressure on the region of the temporomandibular joint (TMJ); and (2) the activity of the digastric muscle evoked by electrical stimulation of the tooth pulp, resulting in the jaw-opening reflex, In the first case, LC stimulation at 10, 30 and 50 muA resulted in a 70%, 68% and 55% reduction in the magnitude of electromyogram (EMG) activity of the masseter muscle compared with the control (without LC stimulation), respectively. The threshold intensity for the onset of masseter EMG activity increased to 106%, 111% and 121% of the control with 10, 30 and 50 muA LC stimulation, respectively, In the second case, EMG magnitude in response to the digastric muscle decreased to 42% of the control when 30 muA Of Le stimulation was delivered. These results suggest that descending influences from the LC can act in suppression of the trigeminal sensorimotor function. (C) 2001 Elsevier Science Inc.