Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.
Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.
复制标题
中枢神经系统内皮细胞和巨噬细胞中的一氧化氮合成对精氨酸类似物抑制的敏感性不同。
DOI：
10.1016/0024-3205(91)90426-c
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
I. McDonald
中科院分区：
文献类型：
--
作者：
L. Lambert;J. Whitten;B. M. Baron;H. Cheng;N. Doherty;I. McDonald
Inhibition of nitric oxide production by arginine analogues was examined in three cell systems; macrophages, CNS tissue and endothelial cells. Nitric oxide production was assessed indirectly using in vitro assays measuring nitrite production (macrophages), cGMP elevation (CNS) and acetylcholine-induced relaxation of aortic ring segments (endothelium). N G-monomethyl-L-arginine and N G-amino-L-arginine possessed similar inhibitory activity in all three assays, while N G-nitro-L-arginine displayed a striking selectivity for inhibition of brain and endothelial cell nitric oxide synthesis, with IC 50 values of 0.05 μM in the CNS versus 200 μM in macrophages. These results suggest that distinct enzymes are responsible for nitric oxide synthesis in different cell types, and indicate that it may be possible to selectively modulate nitric oxide production in vivo.
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NG-氨基-L-精氨酸：L-精氨酸介导的内皮依赖性松弛的新型有效拮抗剂。
DOI：
10.1016/0006-291x(90)92343-x
发表时间：
1990
影响因子：
3.1
作者：
Fukuto,JM;Wood,KS;Byrns,RE;Ignarro,LJ
通讯作者：
Ignarro,LJ
影响因子：
15.9
作者：
GRANGER, DL;HIBBS, JB;DURACK, DT
通讯作者：
DURACK, DT
DOI：
--
发表时间：
1989-11
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Tayeh;M. Marletta
通讯作者：
M. Tayeh;M. Marletta
影响因子：
2.9
作者：
MARLETTA, MA;YOON, PS;WISHNOK, JS
通讯作者：
WISHNOK, JS