Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma
Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma
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DOI：
10.1002/jhbp.305
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发表时间：
2016-02-01
影响因子：
3
通讯作者：
Shibata, Toshihiko
中科院分区：
文献类型：
--
作者：
Kinoshita, Masahiko;Kubo, Shoji;Shibata, Toshihiko
BackgroundWe aimed to identify the pathological features of occupational cholangiocarcinoma.MethodsWe examined the location and distribution of the carcinomas：inapplicable epithelium including biliary intraepithelial neoplasia（BilIN）and intraductal papillary neoplasia of the bile duct（IPNB）; and chronic bile duct injury in operative or autosomal liver samples from 16 patients.我们检查了详细的病理结果和诊断影像的三名患者。免疫组化分析使用一抗H2 AX和S100 P performed.ResultsBilIN和慢性胆管损伤观察16例，IPNB或侵袭性IPNB观察11例。在几乎所有大胆管中观察到BilIN、IPNB和/或慢性胆管损伤。胆管局部扩张，无肿瘤引起的梗阻，显示这种病理变化。在浸润性癌、BilIN和IPNB中H2 AX和S100 P标记物均呈高度阳性，而在非肿瘤性胆管上皮中H2 AX呈阳性，S100 P呈阴性。沿着癌前病变的诱导和浸润性癌的发展。这些病理结果反映了诊断成像的放射学变化。
BackgroundWe aimed to identify the pathological characteristics of occupational cholangiocarcinoma.MethodsWe examined the location and distribution of the carcinomas: atypical epithelium including biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB); and chronic bile duct injuries in operative or autopsy liver specimens from 16 patients. We examined the detailed pathological findings and diagnostic imaging of three patients. Immunohistochemical analysis using primary antibodies against H2AX and S100P was performed.ResultsBilIN and chronic bile duct injury were observed in 16 patients, and IPNB or invasive IPNB was observed in 11 patients. BilIN, IPNB, and/or chronic bile duct injury were observed in almost all the large bile ducts. Regional dilatation of the bile ducts without tumor-induced obstruction revealed such pathological changes. Highly positive results for the H2AX and S100P markers were noted in invasive carcinoma, BilIN, and IPNB, whereas positive results for H2AX and negative results for S100P were noted in non-neoplastic biliary epithelium.ConclusionsThe carcinogenic process of occupational cholangiocarcinoma comprised chronic bile duct injury and DNA damage in almost all the large bile ducts, along with induction of precancerous lesions and development of invasive carcinoma. Such pathological findings reflected radiological changes on diagnostic imaging.