Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters.
Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters.
复制标题
去年非医疗阿片类药物的使用和滥用以及创伤后应激障碍（PTSD）诊断：与性别的相互作用以及与症状群的关联。
DOI：
10.1016/j.addbeh.2016.02.019
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发表时间：
2016
影响因子：
4.4
通讯作者：
Homish,GregoryG
中科院分区：
文献类型：
--
作者：
Smith,KathrynZ;Smith,PhilipH;Cercone,SarahA;McKee,SherryA;Homish,GregoryG
IntroductionFew studies have examined the associations between post-traumatic stress disorder（PTSD）and non-medical opioid use（NMOU），especially in general U.S. samples.MethodsWe analyzed data from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions（NESARC），a national representative sample of non-institutional adults，to examine（1）the relationship between PTSD diagnosis with NMOU，阿片类药物使用障碍诊断和NMOU的平均月频率;（2）PTSD症状群与NMOU，阿片类药物使用障碍诊断和NMOU的平均月频率之间的关系。我们还探讨了这些association.ResultsIn调整后的模型中，过去一年的创伤后应激障碍的诊断与过去一年的NMOU的女性和男性的几率较高，但该协会是更强的女性。此外，PTSD与女性阿片类药物使用障碍诊断的几率较高有关，但与男性无关。关于过去一年PTSD诊断中特定症状群之间的关系，出现了重要的性别差异。对于女性，回避症状簇与NMOU的更高几率相关，阿片类药物使用障碍诊断和NMOU的平均月频率更高，而对于男性，唤醒/反应性簇与NMOU的更高几率相关，阿片类药物使用障碍诊断和NMOU的平均月频率更高。此外，对于男性，回避症状集群与阿片类药物使用障碍诊断的几率更高，但NMOU.ConclusionsResults平均每月频率较低的比率添加到文献中显示PTSD和NMOU之间的关联，并表明PTSD与物质使用的女性比男性更密切相关。此外，基于个体症状群的结果表明，患有PTSD的男性和女性可能出于不同的原因而使用物质。
IntroductionFew studies have examined the associations between posttraumatic stress disorder (PTSD) and non-medical opioid use (NMOU), particularly in general U.S. samples.MethodsWe analyzed data from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative sample of non-institutionalized adults, to examine (1) the relationship between PTSD diagnosis with NMOU, Opioid Use Disorder diagnosis, and average monthly frequency of NMOU; and (2) the relationship between PTSD symptom clusters with NMOU, Opioid Use Disorder diagnosis, and average monthly frequency of NMOU. We also explored sex differences among these associations.ResultsIn the adjusted model, a past year PTSD diagnosis was associated with higher odds of past year NMOU for women and men, but the association was stronger for women. In addition, PTSD was associated with higher odds of an Opioid Use Disorder diagnosis for women, but not for men. With regard to the relationship between specific symptom clusters among those with a past year PTSD diagnosis, important sex differences emerged. For women, the avoidance symptom cluster was associated with higher odds of NMOU, an Opioid Use Disorder diagnosis, and higher rate of average monthly frequency of NMOU, while for men the arousal/reactivity cluster was associated with higher odds of NMOU, an Opioid Use Disorder diagnosis, and a higher rate of average monthly frequency of NMOU. In addition, for men, the avoidance symptom cluster was associated with higher odds of an Opioid Use Disorder diagnosis, but a lower rate of average monthly frequency of NMOU.ConclusionsResults add to the literature showing an association between PTSD and NMOU and suggest that PTSD is more strongly associated with substance use for women than men. Further, results based on individual symptom clusters suggest that men and women with PTSD may be motivated to use substances for different reasons.