Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks.
Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks.
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DOI：
10.1037//0735-7044.97.6.873
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发表时间：
1983-12
影响因子：
1.9
通讯作者：
L. Jarrard
中科院分区：
文献类型：
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作者：
L. Jarrard
采用红藻氨酸(KA)损毁模型，研究损伤CA3细胞场和下丘脑对复杂位置任务和线索任务的影响。在实验1中，应用神经解剖学技术来确定病变的选择性。在受试者内部设计中，实验2的大鼠在手术前接受训练，在一个八臂径向迷宫上运行，程序涉及两种学习(位置和线索)和两种记忆功能(参考记忆和工作记忆)。用KA破坏CA3细胞场来阻断海马区的环路对学习成绩的影响很小；下丘脑底核注射和海马区的完全吸入性损伤导致位置的损害，但不影响提示任务。只有脑室注射KA才会影响这两项任务的表现。这些结果既不支持认知图谱，也不支持海马体功能的工作记忆理论。在直接注射区域以外的远距离损害的存在使结果的解释变得复杂，并可能限制KA作为一种神经毒素在行为研究中的作用。
Kainic acid (KA) lesions were used to study the effects of damage to the CA3 cell field and subiculum on performance of complex place and cue tasks. In Experiment 1, neuroanatomical techniques were employed to determine the selectivity of the lesions. In a within-subjects design, rats in Experiment 2 were trained before the operations to run on an eight-arm radial maze with procedures that involved two kinds of learning (place and cue) and two memory functions (reference memory and working memory). Interrupting the intrahippocampal circuit by damaging the CA3 cell field with KA had minimal effects on performance; injections into subiculum and complete aspiration lesions of hippocampus resulted in impairments on the place but not the cue task. Only intraventricular injections of KA affected performance on both tasks. These results fail to support either the cognitive map or the working memory theory of hippocampal function. The presence of distant damage beyond the immediate area of injection complicates interpretation of the results and may serve to limit the usefulness of KA as a neurotoxin in behavioral investigations.