Relationship between exposure to fine particulates and ozone and reduced lung function in children
Relationship between exposure to fine particulates and ozone and reduced lung function in children
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DOI：
10.1016/j.envres.2015.01.009
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发表时间：
2015-02-01
影响因子：
8.3
通讯作者：
Lee, Yungling Leo
中科院分区：
文献类型：
--
作者：
Hwang, Bing-Fang;Chen, Ya-Hui;Lee, Yungling Leo
背景资料：少数研究报告了长期暴露于环境空气污染物与儿童肺功能发育之间的关系，但结果不确定。目的：为了评估空气污染物暴露和肺功能的增长之间的关系，并检查潜在的性别差异的肺功能增长的易感性，以空气pollution.Methods：我们进行了为期两年的前瞻性队列研究，年龄为12岁的台湾儿童在基线谁是从2007年10月1日至2009年11月31日。研究人群包括2941名在基线和随访调查时完成肺功能检查的非吸烟儿童。我们应用空间模型进行个人水平的暴露评估，以获取相关的暴露，并试图消除潜在的社区水平的混淆。暴露参数为年平均值，并根据24小时PM2.5和8小时臭氧（O-3）浓度计算得出，对应于研究期间的居住地址。效果估计值表示为PM2.5和O-3的每四分位数范围（IQR）的肺功能生长缺陷。在多重线性混合效应模型中，校正混杂因素、用力肺活量（FVC）的生长缺陷、1秒用力呼气量（未通过），用力呼气流量在FVC的第25和第75位之间与PM2.5和O-3的暴露增加相关。例如，更多地暴露于PM2.5（IQR，17.92 μ g/m3）与FVC年增长不足相关，男孩为75 mL，女孩为61 mL（相互作用p
Background: A limited number of studies have reported an association between long-term exposure to ambient air pollutants and lung function growth among children, with inconclusive results. Objectives: To assess the relationship between air pollutant exposure and lung function growth, and to examine potential sex differences in the susceptibility of lung function growth to air pollution.Methods: We conducted a two-year prospective cohort study of Taiwanese children aged 12 at baseline who were followed from October 1, 2007 to November 31, 2009. The study population comprised 2941 non-smoking children who completed pulmonary function tests at both baseline and follow-up surveys. We applied spatial modeling for individual-level exposure assessment to capture relevant exposures and also attempted to eliminate potential community-level confounding. The exposure parameters were annual averages and values calculated from 24-hourly PM2.5 and 8-hourly ozone (O-3) concentrations, corresponding to the residential addresses over the study period. The effect estimates were presented as lung function growth deficits per interquartile range (IQR) for PM2.5 and O-3.Results: In a multiple linear mixed effect model, adjusted for confounding, growth deficits in the forced vital capacity (FVC), forced expiration volume in 1 s (Fail), and forced expiratory flow between the 25th and 75th percentiles of the FVC were associated with increased exposure to PM2.5 and O-3. For example, greater exposure to PM2.5 (IQR, 17.92 mu g/m(3)) was associated with an annual deficit in FVC growth of 75 mL in boys and 61 mL in girls (p for interaction