Nutrition and other risk factors for renal cell carcinoma in postmenopausal women
Nutrition and other risk factors for renal cell carcinoma in postmenopausal women
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DOI：
10.1097/00001648-199701000-00005
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发表时间：
1997-01-01
期刊：
影响因子：
5.4
通讯作者：
Potter, J
中科院分区：
文献类型：
--
作者：
Prineas, RJ;Folsom, AR;Potter, J
1986 年，我们通过邮件收集了爱荷华州 35,192 名绝经后女性（主要是年龄在 55-69 岁且未患癌症的白人）中的基线病史、饮食信息和人体测量数据。我们利用爱荷华州监测、流行病学和最终结果 (SEER) 登记册、国家死亡指数和邮件随访确定了肾细胞癌的 8 年发病率（62 例新病例）。肾细胞癌的危险因素包括年龄增加、体重增加（当前最大成人体重或 18、30 或 50 岁时的体重）、腰臀比增大以及输血史。膳食总钙与肾细胞癌风险降低独立相关。没有其他膳食微量或大量营养素或食物组可以预测肾细胞癌的发生。其他先前确定的危险因素尚未得到证实：最值得注意的是，在调整利尿剂使用后，高血压病史并未增加风险。曾经使用利尿剂的历史与肾癌风险增加一倍相关，尽管在调整年龄、体重、腰臀比和钙摄入量后，关联强度显着降低。
Among 35,192 postmenopausal, predominantly white women in Iowa age 55-69 years and free of cancer, we collected baseline history, dietary information, and anthropometric data by mail in 1986. We ascertained the 8-year incidence (62 new cases) of renal cell carcinoma using the Iowa Surveillance, Epidemiology, and End Results (SEER) register, the National Death Index, and mail follow up. Risk factors for renal cell carcinoma included increasing age, increasing weight (either current, maximum adult weight, or weight at ages 18, 30, or 50 years), greater waist-to-hip ratio, and a history of blood transfusion. Total dietary calcium was associated independently with a reduced risk of renal cell carcinoma. No other dietary micro or macronutrients or food groups were predictive of the development of renal cell carcinoma. Other previously identified risk factors were not confirmed: most notably, there was no increased risk from a history of hypertension, after adjustment for diuretic use. History of ever-use of diuretics was associated with a twofold increased risk of renal cancer, although the strength of association was markedly reduced after adjustment for age, weight, waist-to-hip ratio, and calcium intake.