Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity.
Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity.
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DOI：
10.3164/jcbn.15-13
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发表时间：
2015-07
影响因子：
2.4
通讯作者：
Nagai R
中科院分区：
文献类型：
--
作者：
Ohno R;Moroishi N;Sugawa H;Maejima K;Saigusa M;Yamanaka M;Nagai M;Yoshimura M;Amakura Y;Nagai R
通过日常膳食抑制晚期糖基化终产物（AGEs）被认为是预防生活方式相关疾病的有效方法。在本研究中，山竹（Garcinia mangostana L.）测定了不同浓度的白藜芦醇提取物（韦姆）对AGEs之一戊糖苷（pentosidine）生成的影响以及对皮肤病的治疗作用。韦姆显着抑制戊糖苷形成明胶孵育过程中与核糖。从韦姆中纯化的几种化合物，如garcimangosone D和rhodanthenone B，被鉴定为戊糖苷形成的抑制剂。志愿受试者口服韦姆100 mg/天3个月，血清戊糖苷含量降低。因为从健康志愿者身上获得皮肤活检在伦理上是困难的，所以通过荧光检测器来估计皮肤中的AGE积累。口服韦姆显著降低了皮肤自发荧光强度，表明韦姆也减少了皮肤中AGE的积累。此外，韦姆还提高了皮肤的弹性和含水量。这些结果表明，韦姆的摄入减少了糖化应激，并导致皮肤状况的改善。
The inhibition of advanced glycation end-products (AGEs) by daily meals is believed to become an effective prevention for lifestyle-related diseases. In the present study, the inhibitory effect of hot water extracts of mangosteen (Garcinia mangostana L.) pericarp (WEM) on the formation of pentosidine, one of AGEs, in vitro and in vivo and the remedial effect on skin conditions were measured. WEM significantly inhibited pentosidine formation during gelatin incubation with ribose. Several compounds purified from WEM, such as garcimangosone D and rhodanthenone B, were identified as inhibitors of pentosidine formation. Oral administration of WEM at 100 mg/day to volunteer subjects for 3 months reduced the serum pentosidine contents. Because obtaining skin biopsies from healthy volunteers is ethically difficult, AGE accumulation in the skin was estimated by a fluorescence detector. The oral administration of WEM significantly reduced the skin autofluorescence intensity, demonstrating that WEM also reduced AGE accumulation in the skin. Furthermore, the elasticity and moisture content of the skin was also improved by WEM. These results demonstrate that intakes of WEM reduces the glycation stress and results in the improvement of skin conditions.