The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things.
The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things.
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DOI：
10.1186/s12967-023-04238-9
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发表时间：
2023-06-07
影响因子：
7.4
通讯作者：
Zeng, Zhong
中科院分区：
文献类型：
--
作者：
Fang, Yuan;Zhang, XiaoLi;Huang, HanFei;Zeng, Zhong
肝细胞癌（Hepatocellular carcinoma，HCC）是一种常见的原发性肝癌，是人类癌症相关死亡的主要原因。晚期肝癌缺乏早期诊断，手术切除后复发率高，系统治疗仍是其重要的治疗手段。不同药物因药性不同，疗效、毒副作用及耐药性不同。目前，传统的分子药物治疗肝癌已显示出一定的局限性，如药物不良反应、对某些药物不敏感、耐药性等。非编码RNA（ncRNA）包括microRNA（miRNAs）、长链非编码RNA（lncRNA）和环状RNA（circRNA），它们与肿瘤的发生、发展密切相关。新的生物标志物和治疗靶点，以及对耐药分子基础的研究，迫切需要肝癌的管理。本文综述了ncRNA在肝癌耐药调控中的作用，并从靶向治疗、细胞周期非特异性化疗和细胞周期特异性化疗三个方面探讨了ncRNA在克服肝癌耐药障碍中的潜在临床应用。
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic treatment is still an important treatment method for advanced HCC. Different drugs have distinct curative effects, side effects and drug resistance due to different properties. At present, conventional molecular drugs for HCC have displayed some limitations, such as adverse drug reactions, insensitivity to some medicines, and drug resistance. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), have been well documented to be involved in the occurrence and progression of cancer. Novel biomarkers and therapeutic targets, as well as research into the molecular basis of drug resistance, are urgently needed for the management of HCC. We review current research on ncRNAs and consolidate the known roles regulating drug resistance in HCC and examine the potential clinical applications of ncRNAs in overcoming drug resistance barriers in HCC based on targeted therapy, cell cycle non-specific chemotherapy and cell cycle specific chemotherapy.
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影响因子：
4.9
作者：
通讯作者：
--
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
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通讯作者：
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影响因子：
9.2
作者：
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通讯作者：
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DOI：
10.1186/s13046-019-1193-0
发表时间：
2019-05-09
影响因子：
11.3
作者：
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影响因子：
5
作者：
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