Prohemostatic interventions in trauma: resuscitation-associated coagulopathy, acute traumatic coagulopathy, hemostatic resuscitation, and other hemostatic interventions.
Prohemostatic interventions in trauma: resuscitation-associated coagulopathy, acute traumatic coagulopathy, hemostatic resuscitation, and other hemostatic interventions.
复制标题
创伤中的促止血干预：复苏相关性凝血病、急性创伤性凝血病、止血复苏和其他止血干预措施。
DOI：
10.1055/s-0032-1306435
复制
发表时间：
2012
影响因子：
5.7
通讯作者：
Cohen,MitchellJay
中科院分区：
文献类型：
--
作者：
Howard,BenjaminM;Daley,AaronT;Cohen,MitchellJay
Trauma is the most common cause of death in the young and hemorrhage is the most important cause of death in patients with trauma. Recently redefined pathways of inflammation and coagulation, together with hypothermia and acidosis contribute to trauma-associated coagulopathy and aggravation of bleeding. Pharmacological prohemostatic agents may be useful to (partly) correct the coagulopathy in trauma patients and may serve as useful adjunctive treatment options in patients with severe blood loss after trauma. Recombinant factor VIIa, fibrinogen and prothrombin complex concentrates, and antifibrinolytic agents have been evaluated in clinical trials. These interventions show promising effects but their efficacy in reducing clinically important outcome parameters need to be confirmed in clinical studies.
