POLY(C) IN ANIMAL VIRAL RNAS
POLY(C) IN ANIMAL VIRAL RNAS
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DOI：
10.1038/251342a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
FELLNER, P
中科院分区：
文献类型：
--
作者：
BROWN, F;NEWMAN, J;FELLNER, P
在脑心肌炎病毒1（EMCV）的基因组中发现了大约100个核苷酸，含有80-90个胞酸残基（聚(C)）。我们试图确定这种不寻常的结构特征是否也存在于其他动物小核糖核酸病毒中，包括那些对人类和兽医重要的病毒，如犀牛、口蹄疫和猪水疱病病毒。poly(C)在各种小核糖核酸病毒中的组成和出现的程度可能表明它是否在所有这些病毒共有的任何过程中起作用，如渗透、复制和组装2。此外，如果poly(C)是一种病毒特异性特征，那么基于它的存在设计抗病毒化疗策略可能是可行的。
A TRACT of approximately 100 nucleotides, containing 80–90 cytidylic acid residues (poly(C)) has been found within the genome of encephalomyocarditis virus1(EMCV). We have sought to establish whether this unusual structural feature is also present in other animal picornaviruses, including those of human and veterinary importance, such as rhino-, foot-and-mouth disease and swine vesicular disease viruses. The composition and extent of occurrence of poly(C) in a variety of picornaviruses might indicate whether it has a role in any of the processes which are common to all of these viruses, such as penetration, replication and assembly2. Furthermore, if poly(C) is a virus-specific feature, it might prove feasible to devise antiviral chemotherapeutic strategies based upon its presence.