Endocarditis, drug use and biological sex: A statewide analysis comparing sex differences in drug use-associated infective endocarditis with other drug-related harms.
Endocarditis, drug use and biological sex: A statewide analysis comparing sex differences in drug use-associated infective endocarditis with other drug-related harms.
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心内膜炎、吸毒和生物性别：一项全州范围内的分析，比较了吸毒相关感染性心内膜炎与其他吸毒相关危害的性别差异。
DOI：
10.1016/j.drugpo.2023.104280
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Schranz,AsherJ
中科院分区：
文献类型：
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作者：
McCrary,LMadeline;Cox,MaryE;Roberts,KateE;Knittel,AndreaK;Jordan,RobynA;Proescholdbell,ScottK;Schranz,AsherJ
目的在过去的十年中，药物使用相关的感染性心内膜炎（DUA-IE）的住院率在美国急剧上升。DUA-IE的性别组成仍然不太清楚，研究表明可能会转向更多的女性。我们的目的是比较最近全州范围内DUA-IE的女性与男性的住院率，并将其与北卡罗来纳州（NC）的其他药物相关危害联系起来。使用ICD-10-CM代码识别药物使用相关住院。按年份和性别计算DUA-IE和非DUA-IE的出院率，并与致死性药物过量和急性丙型肝炎（HCV）进行比较。时间，人口统计学，和怀孕的趋势进行了assessed.ResultsHospitalizations率DUA-IE为9.7每10万人在五年期间，女性比男性高1.2倍。在此期间，女性占DUA-IE住院人数的57%。相反，男性的致命药物过量、急性HCV和非DUA-IE住院率较高。年龄，居住县，怀孕状态并没有解释较高的DUA-IE之间females.Conclusionfemales现在包括大多数DUA-IE住院NC，不同于其他药物相关的危害。没有发现明显的人口或地理关联，需要进一步的研究来解释这一现象。应当优先考虑预防注射吸毒女性的侵入性感染。
ObjectivesHospitalizations for drug use-associated infective endocarditis (DUA-IE) have risen sharply across the United States over the past decade. The sex composition of DUA-IE remains less clear, and studies have indicated a possible shift to more females. We aimed to compare more recent statewide hospitalization rates for DUA-IE in females versus males and contextualize them among other drug-related harms in North Carolina (NC).MethodsThis study was a retrospective analysis using public health datasets of all NC hospital discharges for infective endocarditis from 2016 to 2020. Drug use-related hospitalizations were identified using ICD-10-CM codes. Discharge rates by year and sex for DUA-IE and non-DUA-IE were calculated and compared to fatal overdoses and acute hepatitis C (HCV). Temporal, demographic, and pregnancy trends were also assessed.ResultsHospitalizations rates for DUA-IE were 9.7 per 100,000 over the five-year period, and 1.2 times higher among females than males. Females composed 57% of DUA-IE hospitalizations over the period. Conversely, fatal overdose, acute HCV, and non-DUA-IE hospitalization rates were higher among males. Age, county of residence, and pregnancy status did not explain the higher DUA-IE among females.ConclusionFemales now comprise the majority of DUA-IE hospitalizations in NC, unlike other drug-related harms. No clear demographic or geographic associations were found, and further research is needed to explain this phenomenon. Preventing invasive infections among females who inject drugs should be prioritized.