Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials.
Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials.
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DOI：
10.1016/j.nut.2008.04.004
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发表时间：
2008-10
期刊：
影响因子：
4.4
通讯作者：
Jia-Ying Xu;L. Qin;Pei-yu Wang;Wei Li;Chun Chang
中科院分区：
文献类型：
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作者：
Jia-Ying Xu;L. Qin;Pei-yu Wang;Wei Li;Chun Chang
为了更好地了解和总结乳肽摄入量与血压（BP）的关系，我们对随机对照试验进行了荟萃分析，以评估乳源性三肽异亮氨酸-脯氨酸-脯氨酸和缬氨酸-脯氨酸对方法1996年至2005年间发表的12项临床试验，共623名受试者包括在内。两名研究人员独立地从原始出版物中提取数据。由于试验间的同质性，因此采用固定效应模型进行荟萃分析。在汇总这些试验后，发现收缩压显著降低4.8 mmHg（95%置信区间3.7-6.0），舒张压显著降低2.2 mmHg（95%置信区间1.3-3.1）。当试验按血压状态分开时，高血压受试者的降压作用似乎比高血压前期受试者更大。作为一种趋势，降压效果变得更加明显，作为干预longing. CONCLUSION我们的分析提供了证据，乳源性三肽有降压作用，在高血压前期和高血压受试者。
OBJECTIVETo better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.METHODSNine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.RESULTSSignificant decreases of 4.8 mmHg (95% confidence interval 3.7–6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3–3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.CONCLUSIONOur analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects.