Cued reactivation during slow-wave sleep induces brain connectivity changes related to memory stabilization
Cued reactivation during slow-wave sleep induces brain connectivity changes related to memory stabilization
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DOI：
10.1038/s41598-018-35287-6
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发表时间：
2018-11-16
影响因子：
4.6
通讯作者：
Fernandez, Guillen
中科院分区：
文献类型：
--
作者：
Berkers, Ruud M. W. J.;Ekman, Matthias;Fernandez, Guillen
获得后的记忆再处理增强了记忆巩固。具体地说，编码过程中的神经活动被认为是在随后的慢波睡眠中“重放”的。这种记忆重演被认为有助于神经记忆痕迹的功能重组。特别是，记忆重播可能通过诱导大脑连接的重新配置来促进跨大脑区域的信息交换。记忆重新激活可以由外部线索通过一种被称为“定向记忆重新激活”的过程来诱导。在这里，我们分析了一项发表的研究的数据，该研究使用听觉线索来重新激活慢波睡眠期间的视觉物体位置记忆。我们用图论描述了记忆重新激活对大脑网络连通性的影响。我们发现，慢波睡眠中的线索呈现增加了枕叶皮质的全球网络整合，枕叶皮质是一个视觉区域，在提取物体位置时也很活跃。尽管线索对线索与非线索联系的保持没有整体的有利影响，但在过夜记忆稳定方面的个体差异与枕叶皮质网络整合的增强有关。此外，在线索声音呈现过程中，枕叶皮质与助记区，即海马区、海马区、丘脑区和内侧前额叶皮质的连接性增强。综上所述，这些结果表明了一种神经机制，即在睡眠过程中，线索诱导的重播增加了与任务相关的知觉区域和助记区域的整合。这种跨区域的一体化可能有助于巩固和长期储存不朽的记忆。
Memory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be 'replayed' during subsequent slow-wave sleep. Such memory replay is thought to contribute to the functional reorganization of neural memory traces. In particular, memory replay may facilitate the exchange of information across brain regions by inducing a reconfiguration of connectivity across the brain. Memory reactivation can be induced by external cues through a procedure known as "targeted memory reactivation". Here, we analysed data from a published study with auditory cues used to reactivate visual object-location memories during slow-wave sleep. We characterized effects of memory reactivation on brain network connectivity using graph-theory. We found that cue presentation during slow-wave sleep increased global network integration of occipital cortex, a visual region that was also active during retrieval of object locations. Although cueing did not have an overall beneficial effect on the retention of cued versus uncued associations, individual differences in overnight memory stabilization were related to enhanced network integration of occipital cortex. Furthermore, occipital cortex displayed enhanced connectivity with mnemonic regions, namely the hippocampus, parahippocampal gyrus, thalamus and medial prefrontal cortex during cue sound presentation. Together, these results suggest a neural mechanism where cue-induced replay during sleep increases integration of task-relevant perceptual regions with mnemonic regions. This cross-regional integration may be instrumental for the consolidation and long-term storage of enduring memories.