The 2004 Carl A. Moyer award - Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center
The 2004 Carl A. Moyer award - Late outcomes in adult survivors of toxic epidermal necrolysis after treatment in a burn center
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DOI：
10.1097/01.bcr.0000150215.78220.79
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Cartotto, R
中科院分区：
文献类型：
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作者：
Haber, J;Hopman, W;Cartotto, R
尽管烧伤中心治疗后中毒性表皮坏死松解症（TEN）患者的生存率有所提高，但对这些患者的总体长期结局知之甚少。在这项工作中，我们试图分析在我们的烧伤中心接受治疗的TEN幸存者的晚期结局。受试者完成了一份问卷，其中包括兰德36项健康调查（SF-36）和皮肤病生活质量指数。在可能的情况下，对受试者进行检查，并完成功能独立性测量。将SF-36评分与年龄和性别匹配的国家标准数据进行比较。所有结果均表示为平均值+/- SD。1995年1月1日至2003年1月6日期间收治的35名成人中，有10人在医院死亡，4人自出院后死亡，8人失访，研究人群还剩13名受试者（年龄45 +/- 18岁，初始%TBSA受累65 +/- 29）。出院后38 +/- 27个月进行随访。最常见的眼科问题是慢性光敏性（54%）和干眼（31%）。皮肤病生活质量指数（最大-最差评分= 30）为9 +/- 10。SF-36评分显著低于年龄和性别匹配的正常人群，除精神健康外，其他所有领域均如此。功能独立性测量评分（最大-最佳评分= 126）为123 +/- 4。TEN的幸存者在日常生活活动中表现出高水平的独立功能，但TEN的许多并发症显著损害了他们的整体生活质量，强调了长期随访的必要性。
Despite improved survival after burn center treatment for patients with toxic epidermal necrolysis (TEN), little is known about the overall long-term outcomes in these patients. In this work we sought to analyze late outcomes in survivors of TEN who were treated in our burn center. Subjects completed a questionnaire that included the RAND 36-Item Health Survey (SF-36) and the Dermatology Life Quality Index. Subjects were examined, when possible, and completed the Functional Independence Measure. Scores on the SF-36 were compared with age- and sex-matched National normative data. All results are presented as the mean +/- SD. Of 35 adults admitted with TEN between January 1, 1995, and January 6, 2003, 10 have died in hospital, 4 have died since discharge, and 8 have been lost to follow-up, leaving a study population of 13 subjects (age 45 +/- 18 years with initial %TBSA involvement 65 +/- 29). Follow-up occurred at 38 +/- 27 months after discharge. The most common ophthalmic problems were chronic photosensitivity (54%) and dry eyes (31%). The Dermatology Life Quality Index (maximum-worst score = 30) was 9 +/- 10. SF-36 Scores were significantly lower than in the age- and sex-matched normal population across all domains except mental health. The Functional Independence Measure score (maximum-best score = 126) was 123 +/- 4. Survivors of TEN demonstrate a high level of independent function in activities of daily living, but numerous complications of TEN significantly impair their overall quality of life, emphasizing the need for long-term follow-up.