Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior.
Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior.
复制标题
昼长的季节性变化会引起多突触神经递质的切换，从而调节下丘脑网络的活动和行为。
DOI：
10.1126/sciadv.abn9867
复制
发表时间：
2022
期刊：
影响因子：
13.6
通讯作者：
Dulcis,Davide
中科院分区：
文献类型：
--
作者：
Porcu,Alessandra;Nilsson,Anna;Booreddy,Sathwik;Barnes,SamuelA;Welsh,DavidK;Dulcis,Davide
昼长（光周期）的季节性变化影响许多生理功能。视交叉上核(SCN) -室旁核（PVN）轴在处理光周期相关信息中起关键作用。在人类和动物模型中观察到SCN和PVN神经递质表达的季节性变化。然而，SCN-PVN网络响应改变光周期的分子机制尚不清楚。在这里，我们在小鼠中发现，SCN中的神经介质S （NMS）和血管活性肠多肽（VIP）神经元表现出光周期诱导的神经递质可塑性。体内钙动力学记录显示，NMS神经元改变PVN网络活动以响应冬季样光周期。慢性操作NMS神经元足以诱导PVN神经元的神经递质转换并影响运动活动。我们的研究结果揭示了SCN-PVN网络对季节性的分子适应，以及NMS神经元通过影响行为的多突触神经递质交换协调调节下丘脑功能以适应昼夜长度的作用。
Seasonal changes in day length (photoperiod) affect numerous physiological functions. The suprachiasmatic nucleus (SCN)–paraventricular nucleus (PVN) axis plays a key role in processing photoperiod-related information. Seasonal variations in SCN and PVN neurotransmitter expression have been observed in humans and animal models. However, the molecular mechanisms by which the SCN-PVN network responds to altered photoperiod is unknown. Here, we show in mice that neuromedin S (NMS) and vasoactive intestinal polypeptide (VIP) neurons in the SCN display photoperiod-induced neurotransmitter plasticity. In vivo recording of calcium dynamics revealed that NMS neurons alter PVN network activity in response to winter-like photoperiod. Chronic manipulation of NMS neurons is sufficient to induce neurotransmitter switching in PVN neurons and affects locomotor activity. Our findings reveal previously unidentified molecular adaptations of the SCN-PVN network in response to seasonality and the role for NMS neurons in adjusting hypothalamic function to day length via a coordinated multisynaptic neurotransmitter switching affecting behavior.