Elastase Digestion of Fibronectin Releases an Epiviosamine Peptide with Fibroblast Growth and Survival Activity.
Elastase Digestion of Fibronectin Releases an Epiviosamine Peptide with Fibroblast Growth and Survival Activity.
复制标题
纤维连接蛋白的弹性蛋白酶消化释放出具有成纤维细胞生长和存活活性的表维维胺肽。
DOI：
10.1016/j.jid.2018.04.023
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Clark,RichardA
中科院分区：
文献类型：
--
作者：
Lin,Kevin;Lin,Fubao;Clark,RichardA
利用中性粒细胞弹性蛋白酶和基质金属蛋白酶等酶降解细胞外基质在炎症(Cox等人，2008，Tester等人，2007)和组织修复(Wells等人，2016)中发挥重要作用。在蛋白质分解过程中，细胞外基质蛋白经常释放与其母蛋白相比具有不同生物学功能的多肽(Norris等人，1982，Payne等人，2017，Yi和Ruola hti，2001)。纤维连接蛋白(FN)是一种500 kDa的蛋白质，作为临时基质与纤维蛋白一起沉积在损伤部位(Pankov和Yamada，2002，Yamada和Clark，1996)，并由激活的组织细胞原位产生(Kubo等人，1984，Singer等人，1984)。在烧伤期间，FN在最初受伤时沉积在烧伤处，但会被中性粒细胞弹性蛋白酶广泛降解(Grinnell和朱，1994)。以前，我们发现这些片段对人血单核细胞具有趋化活性(Doherty等人，1990，Norris等人，1982)。
Degradation of extracellular matrix with enzymes such as neutrophil elastase and matrix metalloproteinase play an important role in inflammation (Cox et al., 2008, Tester et al., 2007) and tissue repair (Wells et al., 2016). During proteolysis, extracellular matrix proteins often release peptides that have different biological functions compared with their parent protein (Norris et al., 1982, Payne et al., 2017, Yi and Ruoslahti, 2001). These peptides can be beneficial or detrimental to tissue repair (Wells et al., 2016).Fibronectin (FN), a 500-kDa protein, is deposited with fibrin at sites of injury as a provisional matrix (Pankov and Yamada, 2002, Yamada and Clark, 1996) and produced in situ by activated tissue cells (Kubo et al., 1984, Singer et al., 1984). During burn injury, FN is deposited in the burn at the time of initial wounding but subject to extensive degradation by neutrophil elastase (Grinnell and Zhu, 1994). Previously, we showed that such fragments have chemotactic activity for human blood monocytes (Doherty et al., 1990, Norris et al., 1982).