Pattern of polymorphism after strong artificial selection in a domestication event
Pattern of polymorphism after strong artificial selection in a domestication event
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DOI：
10.1073/pnas.0401720101
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发表时间：
2004-07-20
影响因子：
11.1
通讯作者：
Kim, Y
中科院分区：
文献类型：
--
作者：
Innan, H;Kim, Y
强人工选择过程中的驯化事件进行了建模，其影响的DNA多态性的模式进行了研究。该模型还考虑了驯化过程中的种群瓶颈。驯化过程中的人工选择不同于常规的选择性扫描，因为人工选择作用于驯化前可能是中性变体的等位基因。因此，这种有益等位基因的固定并不总是消除周围区域的DNA变异。变异减少的量在很大程度上取决于有益等位基因p的初始频率。因此，p对在驯化过程中从多态性模式检测选择签名的可能性有很强的影响。这些理论结果进行了讨论，从玉米收集的数据。虽然这篇文章的主要重点是驯化，这个模型也可以概括为描述从常设遗传变异的选择性扫描。
The process of strong artificial selection during a domestication event is modeled, and its effect on the pattern of DNA polymorphism is investigated. The model also considers population bottleneck during domestication. Artificial selection during domestication is different from a regular selective sweep because artificial selection acts on alleles that may have been neutral variants before domestication. Therefore, the fixation of such a beneficial allele does not always wipe out DNA variation in the surrounding region. The amount by which variation is reduced largely depends on the initial frequency of the beneficial allele, p. As a consequence, p has a strong effect on the likelihood of detecting the signature of selection during domestication from patterns of polymorphism. These theoretical results are discussed in light of data collected from maize. Although the main focus of this article is on domestication, this model can also be generalized to describe selective sweeps from standing genetic variation.