Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle
Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle
复制标题
DOI：
10.1038/s41598-019-53612-5
复制
发表时间：
2019-11-18
影响因子：
4.6
通讯作者：
Kwon, Ohsang
中科院分区：
文献类型：
--
作者：
Choi, Mira;Choi, Soon-Jin;Kwon, Ohsang
莽草酸（Shikimic acid，SA）是植物干细胞的主要成分。SA对人类毛囊（HF）的确切影响尚不清楚。本研究的目的是检查SA对毛发生长的影响。我们研究了SA对体内C57 BL/6小鼠模型的影响。我们研究了甘露糖受体（MR）（SA的一种已知受体）在人HF中的表达以及SA对人毛乳头细胞（hDPC）、外根鞘细胞（hORSC）和离体人毛器官培养物的影响。SA在体内小鼠模型中显著延长了毛发生长期的毛发生长。我们证实了MR在人HF中的表达，并且SA增加了hDPC和hORSC的增殖。发现SA在离体人毛发器官培养物中增强毛干伸长。SA处理hDPC导致c-myc、肝细胞生长因子、角质形成细胞生长因子和血管内皮生长因子水平增加以及p38 MAPK和cAMP反应元件结合蛋白水平上调。我们的研究结果表明，SA促进毛发生长，并可能作为一种新的治疗剂在治疗脱发。
Shikimic acid (SA) has recently been found to be a major component of plant stem cells. The exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was to examine the effects of SA on hair growth. We investigated the effect of SA on an in vivo C57BL/6 mouse model. We examined the expression of mannose receptor (MR), which is a known receptor of SA, in human HFs and the effect of SA on human dermal papilla cells (hDPCs), outer root sheath cells (hORSCs), and on ex vivo human hair organ culture. SA significantly prolonged anagen hair growth in the in vivo mouse model. We confirmed expression of the MR in human HFs, and that SA increased the proliferation of hDPCs and hORSCs. It was found that SA enhanced hair shaft elongation in an ex vivo human hair organ culture. SA treatment of hDPCs led to increased c-myc, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor levels and upregulation of p38 MAPK and cAMP response element-binding protein levels. Our results show that SA promotes hair growth and may serve as a new therapeutic agent in the treatment of alopecia.