Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
复制标题
DOI：
10.1016/j.jad.2011.09.010
复制
发表时间：
2012-02-01
影响因子：
6.6
通讯作者：
Geffard, Michel
中科院分区：
文献类型：
--
作者：
Maes, Michael;Twisk, Frank N. M.;Geffard, Michel
背景资料：肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）伴有a）针对肠道细菌的脂多糖（LPS）的全身性伊加/IgM应答; B）炎症，例如增加的血浆白细胞介素-（IL）1和肿瘤坏死因子（TNF）α;和c）细胞介导的免疫（CMI）的激活，如通过增加的新蝶呤所证明的。为了研究微生物群、炎症、CMI对LPS的伊加/IgM应答与ME/CFS症状之间的关系，我们测量了6种不同肠细菌对LPS的伊加/IgM应答、血清IL-1、TNF α、新喋呤、对128例ME/CFS和慢性疲劳（CF）患者的血清弹性蛋白酶进行了测定。结果：ME/CFS患者血清IL-1、TNF α、新喋呤和弹性蛋白酶水平均显著高于CF患者。伊加对LPS的反应与血清IL-1之间存在显著的正相关。TNF α，新蝶呤和弹性蛋白酶。具有异常高伊加应答的患者显示血清IL-1、TNF α和新蝶呤水平升高，并且比具有正常伊加应答的受试者对肠易激综合征（IBS）的评级更高。血清IL-1，TNF-α和新喋呤显着相关的疲劳，流感样不适，自主神经症状，神经认知障碍，悲伤和irritability.Conclusions：研究结果表明，增加伊加反应ME/CFS中的肠道细菌与炎症和CMI激活，这与症状的严重程度。它的结论是，增加易位的肠道细菌可能是负责在一些ME/CFS患者的疾病活动。(C)2011 Elsevier B. V.保留所有权利。
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by a) systemic IgA/IgM responses against the lipopolysaccharides (LPS) of commensal bacteria; b) inflammation, e.g. increased plasma interleukin-(IL)1 and tumor necrosis factor (TNF)alpha; and c) activation of cell-mediated immunity (CMI), as demonstrated by increased neopterin.Methods: To study the relationships between the IgA/IgM responses to the LPS of microbiota, inflammation, CMI and the symptoms of ME/CFS we measured the IgA/IgM responses to the LPS of 6 different enterobacteria, serum IL-1, TNF alpha, neopterin, and elastase in 128 patients with ME/CFS and chronic fatigue (CF). Severity of symptoms was assessed by the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.Results: Serum IL-1, TNF alpha, neopterin and elastase are significantly higher in patients with ME/CFS than in CF patients. There are significant and positive associations between the IgA responses to LPS and serum IL-1. TNF alpha, neopterin and elastase. Patients with an abnormally high IgA response show increased serum IL-1, TNF alpha and neopterin levels, and higher ratings on irritable bowel syndrome (IBS) than subjects with a normal IgA response. Serum IL-1, TNF alpha and neopterin are significantly related to fatigue, a flu-like malaise, autonomic symptoms, neurocognitive disorders, sadness and irritability.Conclusions: The findings show that increased IgA responses to commensal bacteria in ME/CFS are associated with inflammation and CMI activation, which are associated with symptom severity. It is concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients. (C) 2011 Elsevier B.V. All rights reserved.