Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects.
Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects.
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空腹脂蛋白脂肪酶蛋白水平可以预测空腹正常高甘油三酯血症受试者的餐后甘油三酯水平增量。
DOI：
10.1002/jcla.21869
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发表时间：
2015
影响因子：
2.7
通讯作者：
Sakane N.
中科院分区：
文献类型：
--
作者：
Tsuzaki K;Kotani K;Yamada K;Sakane N.
背景虽然餐后甘油三酯（TG）水平的增加被认为是动脉粥样硬化形成的危险因素，但评估餐后甘油三酯水平变化的测试（例如脂肪负荷）不能轻易应用于临床实践。因此，需要开发预测餐后 TG 状态的空腹标记物。目前的一个候选者是脂蛋白脂肪酶（LPL）蛋白，一种氢化甘油三酯的分子。本研究调查了空腹LPL水平是否可以预测餐后TG水平。方法共有17名空腹期间甘油三酯正常血症的受试者（11名男性，6名女性，平均年龄52±11岁）接受了进餐测试。测量了包括 LPL 在内的多项空腹参数的餐后 TG 曲线下面积 (AUC-TG)。结果受试者的平均空腹 TG 水平为 1.30 mmol/l，平均 LPL 水平为 41.6 ng/ml。受试者的甘油三酯水平在负荷后增加（餐后两小时后达到峰值）。逐步多元回归分析表明，空腹 TG 水平是 AUC-TG 的预测因子。此外，空腹LPL质量水平被发现是AUC-TG的预测因子（β=0.65，P<0.01），并且这种关系与空腹TG水平无关。结论空腹LPL水平可能有助于预测该人群的餐后TG增量。
BackgroundAlthough a postprandial increment in triglyceride (TG) levels is considered to be a risk factor for atherogenesis, tests (e.g., fat load) to assess postprandial changes in TG levels cannot be easily applied to clinical practice. Therefore, fasting markers that predict postprandial TG states are needed to be developed. One current candidate is lipoprotein lipase (LPL) protein, a molecule that hydrides TGs. This study investigated whether fasting LPL levels could predict postprandial TG levels.MethodsA total of 17 subjects (11 men, 6 women, mean age 52 ± 11 years) with normotriglyceridemia during fasting underwent the meal test. Several fasting parameters, including LPL, were measured for the area under the curve of postprandial TGs (AUC‐TG).ResultsThe subjects’ mean fasting TG level was 1.30 mmol/l, and their mean LPL level was 41.6 ng/ml. The subjects’ TG levels increased after loading (they peaked after two postprandial hours). Stepwise multiple regression analysis demonstrated that fasting TG levels were a predictor of the AUC‐TG. In addition, fasting LPL mass levels were found to be a predictor of the AUC‐TG (β = 0.65,P< 0.01), and this relationship was independent of fasting TG levels.ConclusionFasting LPL levels may be useful to predict postprandial TG increment in this population.