Tissue plasminogen activator in human aqueous humor and its possible therapeutic significance.

Tissue plasminogen activator in human aqueous humor and its possible therapeutic significance.
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人房水中的组织纤溶酶原激活剂及其可能的治疗意义。

DOI:
10.1016/0002-9394(88)90707-6
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发表时间:
1988
影响因子:
4.2
通讯作者:
Millard,CB
Millard,CB
中科院分区:
医学1区
文献类型:
--
作者:
Tripathi,RC;Park,JK;Tripathi,BJ;Millard,CB

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本文用酶联免疫吸附试验检测了10只正常人眼房水中组织型纤溶酶原激活物(tissueplasminogenactivator,tPA)的含量(0.8 ± 0.17ng/ml)。还通过Western印迹分析鉴定了它。组织型纤溶酶原激活物与房水中总蛋白的比率比组织型纤溶酶原激活物与血浆中总蛋白的比率大约30倍。有证据表明,房水中至少有一些组织纤溶酶原激活剂是由眼前房周围的结构局部合成的。组织纤溶酶原激活剂可能是一种有用的治疗方式在临床条件延迟溶解的纤维蛋白在眼睛。
By using an enzyme-linked immunosorbent assay, we detected a significant amount of tissue plasminogen activator (0.8 ± 0.17 ng/ml) in the aqueous humor of ten normal human eyes. It was also identified on Western blot analysis. The ratio of tissue plasminogen activator to total protein in aqueous humor was about 30 times greater than the ratio of tissue plasminogen activator to total protein in plasma. There was evidence that at least some of the tissue plasminogen activator in the aqueous humor was synthesized locally by the structures bordering the anterior chamber of the eye. Tissue plasminogen activator may be a useful therapeutic modality in clinical conditions of delayed dissolution of fibrin in the eye.
DOI: 10.1016/0014-4835(89)90025-0
发表时间: 1989-01-01
影响因子: 3.4
作者:
TRIPATHI, RC;MILLARD, CB;TRIPATHI, BJ
通讯作者: TRIPATHI, BJ
组织纤溶酶原激活剂在实验性前房出血中的应用。
DOI: 10.1001/archopht.1987.01060070139044
发表时间: 1987
期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子: --
作者:
Lambrou,FH;Snyder,RW;Williams,GA
通讯作者: Williams,GA
DOI: 10.1016/0039-6257(78)90177-7
发表时间: 1978
影响因子: 5.1
作者:
M. Pandolfi
通讯作者: M. Pandolfi
DOI: 10.1016/s0161-6420(87)33278-6
发表时间: 1987
期刊: Ophthalmology
影响因子: 13.7
作者:
Tripathi,BJ;Geanon,JD;Tripathi,RC
通讯作者: Tripathi,RC
DOI: 10.1001/archopht.1987.01060090135044
发表时间: 1987
期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子: --
作者:
Snyder,RW;Lambrou,FH;Williams,GA
通讯作者: Williams,GA