A Mini-Review on Cell Cycle Regulation of Coronavirus Infection.

A Mini-Review on Cell Cycle Regulation of Coronavirus Infection.
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冠状病毒感染的细胞周期调控简评

DOI:
10.3389/fvets.2020.586826
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发表时间:
2020
影响因子:
3.2
通讯作者:
Sun D
Sun D
中科院分区:
农林科学2区
文献类型:
--
作者:
Su M;Chen Y;Qi S;Shi D;Feng L;Sun D

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冠状病毒在自然界广泛存在,可感染人类、哺乳动物和家禽。它们对人类和动物造成伤害。病毒介导的细胞周期阻滞是病毒在宿主细胞中存活和增殖的重要策略。病毒诱导的细胞周期阻滞机制的澄清系统对于促进抗病毒治疗的发展是非常必要的。本文系统综述了冠状病毒诱导细胞周期阻滞的分子机制。此外,还讨论了冠状病毒介导的细胞周期阻滞的共同特征。这将为进一步研究冠状病毒的感染机制和预防提供理论依据。
Coronaviruses are widespread in nature and infect humans, mammals and poultry. They cause harm to humans and animals. Virus-mediated cell cycle arrest is an essential strategy for viral survival and proliferation in the host cells. A clarification system of the mechanisms of virus-induced cell cycle arrest is highly desirable to promote the development of antiviral therapies. In this review, molecular mechanisms of coronavirus-induced cell cycle arrest were systematically summarized. Moreover, the common features of coronavirus-mediated cell cycle arrest were discussed. This review will provide a theoretical basis for further studies on the infection mechanisms and prevention of coronaviruses.
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发表时间: 2014
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