Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations
Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations
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DOI：
10.2337/diacare.2.2.154
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发表时间：
1979-03
期刊：
影响因子：
16.2
通讯作者：
T. Welborn;K. Wearne
中科院分区：
文献类型：
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作者：
T. Welborn;K. Wearne
1966 年对澳大利亚巴瑟尔顿人群进行的研究中，除了传统的心血管危险因素外，还测量了口服葡萄糖负荷一小时后的血糖和血清胰岛素水平。冠心病 (CHD) 的 6 年发病率以及 CHD 和所有心血管疾病的 12 年死亡率是根据使用 20 个上百分位值（特定年龄和特定性别）测量的初始基线变量来定义风险比来描述的。在年轻受试者（年龄小于 60 岁）中，男女血压水平升高（风险比从 2.9 至 5.2）和男性血清胆固醇浓度升高（风险比从 3.0 至 3.3）是心血管风险的强有力预测因素。在 60 至 69 岁的男性中，一小时血清胰岛素浓度上限与 CHD 的 6 年发病率、CHD 的 12 年死亡率以及所有心血管疾病的 12 年死亡率显着相关（风险比分别为 2.0、2.3 和 2.4）。当对所有年龄段的男性进行分析时，血清胰岛素升高与心血管死亡率之间的关系仍然存在，并且它似乎独立于其他主要危险因素。在女性中，未发现血清胰岛素与冠心病或心血管疾病之间存在关联。尽管一小时血糖浓度的年龄和性别特定的上 20 个百分位值与随后的心血管疾病终点之间显示出低等级关联，但在 200 mg/100 ml 或更高的较高血糖水平下显示出更明显的风险比（在 60 岁及以上年龄组中，男性风险比为 2.2，女性风险比为 2.6。
In the 1966 study of the population of Busselton, Australia, blood sugar and serum insulin levels were measured one hour after an oral glucose load, in addition to the conventional cardiovascular risk factors. The six-year incidence of coronary heart disease (CHD) and the 12-yr mortality from CHD and from all cardiovascular diseases is described in relation to the initial baseline variables measured using the upper 20th percentile values (age-specific and sex-specific) to define the risk ratios. In younger subjects (ages less than 60 yr), elevated blood pressure levels for both sexes (risk ratios from 2.9 to 5.2) and elevated serum cholesterol concentrations for males (risk ratios from 3.0 to 3.3) were strong predictors of cardiovascular risk. In men aged 60 to 69 yr, those with upper range one-hour serum insulin concentrations showed marked associations with the six-year incidence of CHD, the 12-yr mortality from CHD, and the 12-yr mortality from all cardiovascular diseases (risk ratios were 2.0, 2.3, and 2.4, respectively). The relationship of elevated serum insulin and cardiovascular mortality persisted when males of all ages were analyzed, and it appeared to be independent of the other major risk factors. In females, no association between serum insulin and CHD or cardiovascular disease could be found. Although the age and sex specific upper 20th percentile values for one-hour blood sugar concentrations showed a low grade association in patients with subsequent cardiovascular disease end points, more noticeable risk ratios were demonstrated at the higher blood sugar level of 200 mg/100 ml or greater (in the age group 60 yr and over, risk ratios were 2.2 in males and 2.6 in females.