DEVELOPMENTAL PLASTICITY OF CENTRAL SEROTONIN NEURONS AFTER 5,7‐DIHYDROXYTRYPTAMINE TREATMENT *
DEVELOPMENTAL PLASTICITY OF CENTRAL SEROTONIN NEURONS AFTER 5,7‐DIHYDROXYTRYPTAMINE TREATMENT *
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5,7-二羟基色胺治疗后中枢血清素神经元的发育可塑性*
DOI：
10.1111/j.1749-6632.1978.tb31532.x
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发表时间：
1978
影响因子：
5.2
通讯作者：
C. Sachs
中科院分区：
文献类型：
--
作者：
G. Jonsson;T. Pollare;H. Hallman;C. Sachs
新生大鼠全身注射5，7-羟色胺后，中枢神经系统中5-羟色胺神经元的发育发生改变，具有明显的地区差异。5，7-羟色胺在新生儿阶段全身给药后，由于血脑屏障的不完全发育，可进入大脑并引发神经毒性作用，5，7-羟色胺的作用在出生后5天至7天之间详细阐述。出生时使用5，7-羟色胺可导致大脑皮层和脊髓显著和永久性的5-羟色胺失神经，而5-羟色胺细胞体附近区域(中脑-桥脑-延髓)发生超神经支配。后一种影响在出生后第一周内可见。5，7-羟色胺处理也以类似的方式影响NA神经元，尽管这种作用优先于5-羟色胺神经元。DMI对5-羟色胺神经元具有选择性作用，之后NA和DA神经元均能正常发育。没有观察到生长中的5-羟色胺、去甲肾上腺素和多巴胺神经元之间有任何相互作用的迹象。突触后5-羟色胺受体与[~3H]-5-羟色胺和[~3H]LSD结合的体外研究表明，该受体的发育不依赖于突触前5-羟色胺神经末梢。5-羟色胺去神经支配和5-羟色胺超敏神经支配均不伴有受体结合特性或受体密度的改变。现有的结果与以下观点是一致的，即新生儿服用5，7-羟色胺后，5-羟色胺神经元的后果主要是由于“修剪效应”。发育中的5-羟色胺神经元似乎被编程为产生一定数量的神经末梢分支，在5-羟色胺诱导的损伤后，它们试图保存这些分支，导致观察到的5-羟色胺神经末梢的重排。
Systemic administration of 5,7-HT to newborn rats produces an altered development of the 5-HT neurons in the central nervous system, with marked regional differences. 5,7-Hydroxytryptamine can enter the brain and elicit its neurotoxic actions after systemic administration in the neonatal stage due to an incompletely developed blood-brain barrier, which for 5,7-HT is elaborated between postnatal Days 5 and 7. Treatment with 5,7-HT at birth produces marked and permanent 5-HT denervation in the cerebral cortex and spinal cord, whereas hyperinnervation occurs in the 5-HT cell body-near regions (mesencephalon-pons-medulla). The latter effect is seen within the first week postnatally. Treatment with 5,7-HT also affects NA neurons in a similar manner, although the action is exerted preferentially on 5-HT neurons. A selective effect on 5-HT neurons can be achieved by DMI pretreatment, after which both NA and DA neurons develop normally. No signs of any interaction among growing 5-HT, NA, and DA neurons can be observed. Studies of the postsynaptic 5-HT receptor in vitro with [3H]-5-HT and [3H]LSD binding indicate that this receptor develops independently of presynaptic 5-HT nerve terminals. Neither 5-HT denervation nor 5-HT hyperinnervation was accompanied by any change in receptor-binding characteristics or receptor density. The results available are compatible with the view that the consequences for 5-HT neurons that occur after neonatal 5,7-HT administration are mainly due to a "pruning effect." The developing 5-HT neurons seem to be programmed to produce a certain quantity of nerve terminal arborizations, which they try to conserve after 5-HT-induced injury, leading to the observed rearrangement of 5-HT nerve terminals.