Noninvasive Dynamic Imaging of Tumor Early Response to Nanoparticle-mediated Photothermal Therapy.
Noninvasive Dynamic Imaging of Tumor Early Response to Nanoparticle-mediated Photothermal Therapy.
复制标题
肿瘤对纳米颗粒介导的光热疗法早期反应的无创动态成像
作者：
Zhang F;Cao J;Chen X;Yang K;Zhu L;Fu G;Huang X;Chen X
尽管纳米粒子介导的光热疗法(PTT)用于治疗不同类型的肿瘤的兴趣迅速增加，但对早期治疗相关的肿瘤反应变化知之甚少。本研究以氧化石墨烯(GO)为模型纳米粒子(NP)，通过磁共振成像(MRI)跟踪GO-NP介导的PTT后肿瘤的变化，并定量确定MRI多参数，以评估不同加热水平和持续时间下肿瘤内MRI信号的动态变化。我们发现，在肿瘤发生任何形态变化之前，肿瘤内微环境中的MRI信号强度随时间和温度的动态变化，这主要是由于快速有效地消除了肿瘤血管。基于GO颗粒的分布，我们还证明了NP介导的PTT导致了肿瘤的异质性热损伤。总之，这些新发现不仅为非侵入性早期追踪、识别和监测NP介导的PTT的治疗反应提供了一种与临床相关的方法，而且为更好地理解NP介导的PTT的机制提供了新的视角。
In spite of rapidly increasing interest in the use of nanoparticle-mediated photothermal therapy (PTT) for treatment of different types of tumors, very little is known on early treatment-related changes in tumor response. Using graphene oxide (GO) as a model nanoparticle (NP), in this study, we tracked the changes in tumors after GO NP-mediated PTT by magnetic resonance imaging (MRI) and quantitatively identified MRI multiple parameters to assess the dynamic changes of MRI signal in tumor at different heating levels and duration. We found a time- and temperature-dependent dynamic change of the MRI signal intensity in intratumor microenvironment prior to any morphological change of tumor, mainly due to quick and effective eradication of tumor blood vessels. Based on the distribution of GO particles, we also demonstrated that NP-medited PTT caused heterogeneous thermal injury of tumor. Overall, these new findings provide not only a clinical-related method for non-invasive early tracking, identifying, and monitoring treatment response of NP-mediated PTT but also show a new vision for better understanding mechanisms of NP-mediated PTT.