Three Arabidopsis MBF1 homologs with distinct expression profiles play roles as transcriptional co-activators.
Three Arabidopsis MBF1 homologs with distinct expression profiles play roles as transcriptional co-activators.
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DOI：
10.1093/pcp/pch017
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发表时间：
2004-02
影响因子：
4.9
通讯作者：
K. Tsuda;T. Tsuji;S. Hirose;K. Yamazaki
中科院分区：
文献类型：
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作者：
K. Tsuda;T. Tsuji;S. Hirose;K. Yamazaki
多蛋白桥接因子 1 (MBF1) 已知是一种转录共激活因子，通过激活因子和 TATA-box 结合蛋白 (TBP) 之间的桥接来介导转录激活。我们证明，拟南芥中每三个 MBF1 的表达可以部分挽救酵母 mbf1 突变表型，表明它们都充当 GCN4 依赖性转录激活的共激活子。我们还报告说，它们的每种亚型都显示出不同的组织特异性表达模式和对植物激素的反应。这些观察结果表明，尽管它们具有相似的生化功能，但每个 MBF1 在不同的组织和条件中具有不同的作用。
Multiprotein bridging factor 1 (MBF1) is known to be a transcriptional co-activator that mediates transcriptional activation by bridging between an activator and a TATA-box binding protein (TBP). We demonstrated that expression of every three MBF1 from Arabidopsis partially rescues the yeast mbf1 mutant phenotype, indicating that all of them function as co-activators for GCN4-dependent transcriptional activation. We also report that each of their subtypes shows distinct tissue-specific expression patterns and responses to phytohormones. These observations suggest that even though they share a similar biochemical function, each MBF1 has distinct roles in various tissues and conditions.