DELETERIOUS EFFECTS OF ANABOLIC-STEROIDS ON SERUM-LIPOPROTEINS, BLOOD-PRESSURE, AND LIVER-FUNCTION IN AMATEUR BODY BUILDERS
DELETERIOUS EFFECTS OF ANABOLIC-STEROIDS ON SERUM-LIPOPROTEINS, BLOOD-PRESSURE, AND LIVER-FUNCTION IN AMATEUR BODY BUILDERS
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DOI：
10.1055/s-2007-1024972
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发表时间：
1988-02-01
影响因子：
2.5
通讯作者：
THIEN, T
中科院分区：
文献类型：
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作者：
LENDERS, JWM;DEMACKER, PNM;THIEN, T
研究了自服合成类固醇(AS)对男性业余健美运动员脂蛋白、肝功能和血压的影响。20名健美运动员在AS疗程结束时被研究(组1)，42名健美运动员在AS停药后平均5个月被研究(组2)。16名健美运动员在停止AS至少2个月后和AS为期9周的疗程结束时被研究(第3组)。一组13名从未使用过AS的健美运动员作为对照组。第1组和第2组的转氨酶水平和收缩压均高于对照组(P<；0.05)。治疗1个疗程后，第3组转氨酶升高，收缩压(+3 mm Hg)和心率(+7bts/min)略有升高(P<；0.05)。高密度脂蛋白胆固醇(HDLC)显著低于对照组和对照组(P&0.001)，低密度脂蛋白胆固醇(LDLC)显著高于对照组(P<0.001)，载脂蛋白A-1/B比值(ApoA-I/ApoB)低于对照组(P<；0.001)。第3组高密度脂蛋白胆固醇由1.18.+-下降。0.05至0.60。+-。0.08mmo1/L(P<；0.001)，低密度脂蛋白胆固醇从3.97.+-升高。0.39至5.74。+-。0.71mmol.L(P<；0.01)。低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率从3.6.+-上升。0.5至15.8。+-。4.0(P<；0.01)，载脂蛋白A-I/载脂蛋白B比值从1.42±-下降。0.11至0.66。+-0.15在AS一个疗程后。AS对业余健美运动员的血压、血脂和肝脏代谢的这些深刻的不良影响表明，服用AS的业余运动员过早发生动脉粥样硬化和肝脏毒性的长期风险严重增加。
The effects of self-administered anabolic steroids (AS) on lipoproteins, liver function, and blood pressure were studied in male amateur body builders. Twenty body builders were studied at the end of a course of AS (group 1) and 42 body builders were studied after discontinuation of the AS for a mean of 5 months (group 2). Sixteen body builders were studied after discontinuation of AS for at least 2 months and at the end of a 9-week course of AS (group 3). A group of 13 body builders who never used AS served as a control group. Both groups 1 and 2 showed higher levels of transaminas and a higher systolic blood pressure than the controls (P < 0.05). Group 3 showed an increase of the transaminases an a slight but significant increase of systolic blood pressure (+3 mm Hg) and heart rate (+7 bts/min) after one course of AS (P < 0.05). Group 1 showed a considerably lower hihg-density lipoprotein cholesterol (HDLC) (P < 0.001), a higher low-density lipoprotein cholesterol (LDLC) (P < 0.05), and a lower apoprotein A-1/B ratio (Apo A-I/ApoB) (P < 0.001) than the controls and group 2. The ratio of LDLC/HDLC in group 1 was fourfold higher than in the controls (P < 0.01). In group 3 HDLC decreased from 1.18 .+-. 0.05 to 0.60 .+-. 0.08 mmol/l (P < 0.001) and LDLC increased from 3.97 .+-. 0.39 to 5.74 .+-. 0.71 mmol/l (P < 0.01). The LDLC/HDLC ratio increased from 3.6 .+-. 0.5 to 15.8 .+-. 4.0 (P < 0.01) and the ApoA-I/ApoB ratio decreased from 1.42 .+-. 0.11 to 0.66 .+-. 0.15 after one course of AS. These profound adverse effects of AS on blood pressure, lipid, and liver metabolism in amateur body builders suggest a seriously increased long-term risk for premature atherogenesis and hepatotoxicity in amateur athletes using AS.