Reduced planum temporale volume and delusional behaviour in patients with schizophrenia
Reduced planum temporale volume and delusional behaviour in patients with schizophrenia
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DOI：
10.1007/s00406-007-0723-5
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发表时间：
2007-04
影响因子：
4.7
通讯作者：
S. Yamasaki;H. Yamasue;O. Abe;Haruyasu Yamada;A. Iwanami;Y. Hirayasu;Motoaki Nakamura;Shun-ichi Furukawa;M. Rogers;Y. Tanno;S. Aoki;N. Kato;K. Kasai
中科院分区：
文献类型：
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作者：
S. Yamasaki;H. Yamasue;O. Abe;Haruyasu Yamada;A. Iwanami;Y. Hirayasu;Motoaki Nakamura;Shun-ichi Furukawa;M. Rogers;Y. Tanno;S. Aoki;N. Kato;K. Kasai
颞平面（PT）是颞上异模联合皮层的一部分，参与听觉和语言处理，其结构异常与精神分裂症的病理生理有关。然而，其与临床表现的关系尚不清楚。对17名患有精神分裂症的右撇子日本男性和22名年龄、利手性和父母社会经济地位匹配的健康日本男性进行磁共振成像，以人工评估Heschl’s gyrus （HG）和PT的灰质体积。采用阳性和阴性综合征量表评估患者的精神症状。与健康参与者相比，精神分裂症患者的左脑或右脑灰质体积减少具有统计学意义，而HG体积保持不变。右侧PT体积越小，患者妄想行为越严重。先前的研究主要集中在精神分裂症病理生理学中小于正常的左侧PT；然而，目前的结果表明，在精神分裂症患者的精神病经历中，正确的PT可能发挥作用，它涉及社会认知，如理解他人的意图。
The structural abnormality of planum temporale (PT), a part of the superior temporal heteromodal association cortex involved in auditory and language processing, has been implicated in the pathophysiology of schizophrenia. However, its relationship to clinical manifestations remains unclear. Magnetic resonance images were obtained from 17 right-handed Japanese men with schizophrenia and from 22 age-, handedness-, and parental socioeconomic-status-matched healthy Japanese men in order to manually evaluate grey matter volumes of Heschl’s gyrus (HG) and PT. Psychiatric symptoms were assessed using positive and negative syndrome scale among the patients. Compared with healthy participants, patients with schizophrenia were associated with a statistically significant PT grey matter volume reduction without left or right lateralization, whereas HG volume was preserved. Smaller right PT volume was significantly correlated with more severe delusional behaviour in the patients. Previous investigations have focused on smaller-than-normal left PT in the pathophysiology of schizophrenia; however, the present results suggest a possible role of the right PT, which is involved in social cognition such as understanding the intentions of others, in the production of psychotic experiences in patients with schizophrenia.