Metastasis Stemming from Circulating Tumor Cell Clusters.

Metastasis Stemming from Circulating Tumor Cell Clusters.
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DOI:
10.1016/j.tcb.2019.02.001
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发表时间:
2019-04
影响因子:
19
通讯作者:
Yu M
Yu M
中科院分区:
生物学1区
文献类型:
--
作者:
Yu M

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与单个细胞相比,循环肿瘤细胞群(CTC)具有更强的启动转移能力,但尚不清楚它们是如何获得这种优势的。Gkountela等人最近的一项研究。(CELL 2019;176:98-112)将簇的物理状态与干细胞相关转录因子的更多可获得性联系起来,为CTC簇中“干性”的表观遗传调控提供了新的见解。
Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela et al. (Cell 2019;176:98–112) links the physical state of clusters with increased accessibility of stem cellrelated transcription factors, providing novel insights into the epigenetic regulation of ‘stemness’ in CTC clusters.
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