Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy
Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy
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结肠癌细胞中 Mps1 的过度表达会减弱纺锤体组装检查点并增加非整倍性
DOI：
10.1016/j.bbrc.2014.07.071
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发表时间：
2014-08-08
影响因子：
3.1
通讯作者：
Xu, Quanbin
中科院分区：
文献类型：
--
作者：
Ling, Youguo;Zhang, Xiaojuan;Xu, Quanbin
纺锤体组装检查点激酶Mps1在几种类型的癌症中高度表达，但其在肿瘤发生中的细胞参与较少。在此，我们确认Mps1在结肠癌组织中过表达。此外，我们发现在结肠癌细胞系SW 480中强制表达Mps1使细胞能够对Mps1抑制诱导的检查点耗竭和细胞死亡产生抗性。Mps1的过表达也增加了肿瘤细胞中基因组的不稳定性，这是由于纺锤体组装检查点减弱。总的来说，我们的研究结果表明，高水平的Mps1有助于通过衰减纺锤体组装检查点的肿瘤发生。(C)2014爱思唯尔公司All rights reserved.
The spindle assembly checkpoint kinase Mps1 is highly expressed in several types of cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that Mps1 is overexpressed in colon cancer tissues. Further, we find that forced expression of Mps1 in the colon cancer cell line SW480 enables cells to become resistant to both Mps1 inhibition-induced checkpoint depletion and cell death. Overexpression of Mps1 also increases genome instability in tumor cells owing to a weakened spindle assembly checkpoint. Collectively, our findings suggest that high levels of Mps1 contribute to tumorigenesis by attenuating the spindle assembly checkpoint. (C) 2014 Elsevier Inc. All rights reserved.