High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber.
High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber.
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DOI：
10.1364/boe.4.000260
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发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Psaltis D
中科院分区：
文献类型：
--
作者：
Papadopoulos IN;Farahi S;Moser C;Psaltis D
我们提出并实验证明了一种基于无源多模光纤的超薄刚性内窥镜（直径450 μm）。我们使用数字相位共轭来克服光纤的模式混乱，以在其远端紧密聚焦和扫描激光。通过利用最大数量的可用模式，亚微米分辨率，高质量的神经元细胞的荧光图像被获取。成像系统的荧光收集效率，分辨率和视野方面进行评估。所提出的内窥镜的小直径以及其高质量图像沿着提供了通过直接组织穿透进行基于细胞表型的微创医学内窥镜成像和诊断的机会。
We propose and experimentally demonstrate an ultra-thin rigid endoscope (450 μm diameter) based on a passive multimode optical fiber. We use digital phase conjugation to overcome the modal scrambling of the fiber to tightly focus and scan the laser light at its distal end. By exploiting the maximum number of modes available, sub-micron resolution, high quality fluorescence images of neuronal cells were acquired. The imaging system is evaluated in terms of fluorescence collection efficiency, resolution and field of view. The small diameter of the proposed endoscope, along with its high quality images offer an opportunity for minimally invasive medical endoscopic imaging and diagnosis based on cellular phenotype via direct tissue penetration.