Chemokines in lymphocyte trafficking and intestinal immunity
Chemokines in lymphocyte trafficking and intestinal immunity
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DOI：
10.1038/sj.mn.7800196
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发表时间：
2003-07-01
期刊：
影响因子：
2.4
通讯作者：
Butcher, EC
中科院分区：
文献类型：
--
作者：
Kunkel, EJ;Campbell, DJ;Butcher, EC
淋巴细胞通过肠道相关淋巴组织(GALT)迁移到肠道效应部位，对肠道免疫系统功能和体内平衡至关重要。趋化因子通过激活整合素在血管系统中的激活和牢固的阻止，并介导组织内的趋化定位，从而促进淋巴细胞的运输。已发现几种趋化因子在GALT和/或肠道中表达(Teck/CCL25、MEC/CCL28和MIP-3α/CCL20)，并在肠道淋巴细胞定位中发挥作用，包括肠道和其他粘膜相关效应部位的统一；肠道的节段性特化；以及肠道亚群的选择性定位。本文综述了这些趋化因子(及其受体CCR9、CCR10和CCR6)在淋巴细胞归巢到GALT、肠道效应淋巴细胞和记忆淋巴细胞的诱导和分化以及淋巴细胞在肠道内稳态和炎症定位中的作用。
Lymphocyte migration through gut-associated lymphoid tissues (GALT) and into intestinal effector sites is critical to intestinal immune system function and homeostasis. Chemokines contribute to lymphocyte trafficking by triggering integrin activation and firm arrest in the vasculature and mediating chemotactic localization within tissues. Several chemokines have been identified that are expressed in the GALT and/or the intestines themselves (TECK/CCL25, MEC/CCL28, and MIP-3alpha/CCL20) and play a role in intestinal lymphocyte localization, including unification of intestinal and other mucosa-associated effector sites; segmental specialization of the intestines; and subset selective localization to the intestines. This review examines the role of these chemokines ( and their receptors CCR9, CCR10, and CCR6, respectively) in lymphocyte homing to the GALT, in the induction and differentiation of intestinal effector and memory lymphocytes, and in the homeostatic and inflammatory localization of lymphocytes to the intestines.