Skin tolerance to fractionated x-irradiation in the pig--how good a predictor is the NSD formula?
Skin tolerance to fractionated x-irradiation in the pig--how good a predictor is the NSD formula?
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猪皮肤对分段 X 射线照射的耐受性——NSD 公式的预测效果如何？
DOI：
10.1259/0007-1285-47-555-185
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
T. Patterson
中科院分区：
文献类型：
--
作者：
R. Berry;G. Wiernik;T. Patterson
用250 kVPX射线分1次、6次或30次照射家猪的腰部。急性皮肤反应使用数值方案进行量化评分。晚期皮肤耐受性，在暴露后长达一年，由照射野中皮肤坏死的存在或不存在来确定。标称标准剂量对早期皮肤反应的预测很差；在18天内分6次给药以产生干燥或潮湿脱屑所需的等效剂量比在39天内分30次给药所需的剂量高出约30%。与单次辐射剂量相比，差异更大。晚期皮肤耐受性与早期反应水平并不密切相关，但NSD公式可以很好地预测皮肤坏死。猪身上的这些数据与三个大型放射治疗中心临床确定的晚期皮肤耐受性很好地相关。然而，对于平方厘米的皮肤场，猪的皮肤耐受性…
Abstract Fields on the flanks of domestic swine were irradiated with 250 kVp X rays in courses of one, six, or 30 fractions. The acute skin response was scored quantitatively using a numerical scheme. Late skin tolerance, up to one year after exposure, was determined by the presence or absence of skin necrosis in the irradiated fields. The Nominal Standard Dose was a poor predictor for early skin response; an approximately 30 per cent higher equivalent dose was required when administered in six fractions over 18 days to produce either dry or moist desquamation, than was required when given in 30 fractions over 39 days. The difference was even greater when compared with single radiation doses. Late skin tolerance was not closely correlated with the level of early response, but skin necrosis was well predicted by the NSD formula. These data in the pig correlate well with clinically determined late skin tolerance in three large radiotherapy centres. For a 64 cm2 skin field, however, skin tolerance in the pig...