FLEXIBILITY OF DNA
FLEXIBILITY OF DNA
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DOI：
10.1002/bip.1974.360130115
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发表时间：
1974-01-01
期刊：
影响因子：
2.9
通讯作者：
SCHELLMAN, JA
中科院分区：
文献类型：
--
作者：
SCHELLMAN, JA
提出了一种DNA柔性模型，该模型基于从一个亚基到下一个亚基在传播方向上的离散变化。局域自由能按局域弯曲展开，得到一个高斯分布函数。局部弯曲独立于邻居的假设导致了持续长度和特征比的非常简单的公式。然而，重点放在有限大小分子的公式的应用上，其中没有定义持续长度和Dc∞。公式是针对两个模型得出的，这两个模型应作为实际物理情况的限制。
A model for the flexibility of DNA is proposed that is based on discrete variations in the direction of propagation in going from one subunit to the next. Expansion of the local free energy in terms of the local bending gives a Gaussian distribution function. The assumption of the independence of local bends on neighbors lead to very simple formulae for the persistence length and the characteristic ratio. Emphasis, however, is placed on the application of the formulae for molecules of finite size where the persistence length andC∞are not defined. The formulae are worked out for two models, which should serve as limits for the real physical situation.